China Tolterodine Tartrate ile-iṣẹ ati awọn olupese

Tartte Tolterodine

Apejuwe Kukuru:

Appearance White or almost white crystalline powder ,odourless. Solubility Sparingly soluble in methonal, slightly soluble inwater, pratically insoluble in chloroform Melting point 205~ 2 10 ºC ,decomposed during the melting process Specific rotation + 27.0º~+ 30.0º Identification Chemical reaction Solution appears purpureal Characteristic absorption Exhibits a maximum at 282nm IR The IR absorption spectrum of tolterodin tartrate should concordant with that (IR Album N...

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Ọja Apejuwe

Ọja Tags

Irisi	Funfun tabi fere funfun lulú okuta, odorless.
Solubility	Ṣiparọ tiotuka ninu methonal, omi inu tio tutun diẹ, insoluble pratically ni chloroform
Yo ojuami	205 ~ 2 10 ºC, ti bajẹ lakoko ilana fifọ
Yiyi ni pato	+ 27.0º ~ + 30.0º
Idanimọ
Kemikali lenu	Ojutu han purpureal
Iwa gbigba ihuwasi	Awọn ifihan ti o pọju ni 282nm
IR	Iwọn iwoye IR ti tolterodin tartrate yẹ ki o ni ibamu pẹlu iyẹn (IR Album No.1037) ti nkan itọkasi
Irisi digi fadaka ti tartrate	Ṣafikun amonia omi pẹlu fadaka nitrat ọpọlọpọ awọn sil put, fi sii inu iwẹ omi ati igbona, awọn ipin fadaka ati awọn asopọ si odi inu ti tube, awọn fọọmu digi fadaka
Idanwo
Acidity	PH: 3.0-4.5
Lhloride	Ko yẹ ki o ni itara diẹ sii ju itọkasi kan nipa lilo 2.0ml ti ojutu boṣewa sodium kiloraidi (0.025%)
Imi-ọjọ	Ko yẹ ki o ni itara diẹ sii ju itọkasi kan nipa lilo 1.0ml ti ojutu boṣewa sulphate sulphate (0.05%)
Isomer Laevo	NMT1.0%
Jẹmọ oludoti	Eyikeyi aimọ miiran: NMT0.1%
	Lapapọ awọn impurities: NMT 0,5%
Iṣẹ	Tolterodine jẹ alatako olugba olugba ifigagbaga M, ati yiyan rẹ si àpòòtọ ni okun sii pataki ju ti ẹṣẹ itọ lọ. Idinamọ rẹ ti ihamọ apo-iwe jẹ nipa awọn akoko 20 ti ti ẹṣẹ itọ. Lẹhin iṣakoso ẹnu ti tolterodine, itọsẹ akọkọ ti nṣiṣe lọwọ 5-hydroxymethyl itọsẹ (DD01) ti a ṣe nipasẹ ẹdọ jẹ iru si iṣẹ antimuscarinic obi ati pe o ni pataki itọju ilera. Awọn mejeeji ni ibatan kekere fun awọn olugba iṣan neurotransmitter miiran ati awọn ibi-afẹde ti o ni agbara cellular gẹgẹbi awọn ikanni kalisiomu.