China Tolterodine Tartrate wheketere me nga kaihanga

Tolterodine Tartrate

Whakaahuatanga Poto:

Appearance White or almost white crystalline powder ,odourless. Solubility Sparingly soluble in methonal, slightly soluble inwater, pratically insoluble in chloroform Melting point 205~ 2 10 ºC ,decomposed during the melting process Specific rotation + 27.0º~+ 30.0º Identification Chemical reaction Solution appears purpureal Characteristic absorption Exhibits a maximum at 282nm IR The IR absorption spectrum of tolterodin tartrate should concordant with that (IR Album N...

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Taipitopito Hua

Tohu Hua

Te Ahua	Ma te paura tioata ma ma ranei, ma te kore he kakara.
Te wairewa	He iti nei te wairewa i te methonal, te wai waireka paku, kaore e rewa ana i te chloroform
Wāhi rewa	205 ~ 2 10 ºC, pirau i te wa rewa
Te hurihanga motuhake	+ 27.0º ~ + 30.0º
Tuakiri
Tauhohenga matū	He rongoa te tikanga
Te mimiti ngongo	Ka whakaatu i te rahinga nui i te 282nm
IR	Ko te rerenga rerenga IR o te tolterodin tartrate kia rite ki tera (IR Album No.1037) o te matū tohutoro
Tauhohenga whakaata hiriwa o te tartrate	Taapirihia he haumanu wai me nga pata waikawa hiriwa, hoatu ki roto i te pati wai me te wera, wehe te hiriwa ka piri ki te pakitara o te ngongo, he whakaata hiriwa
Whakamatau
Te waikawa	PH: 3.0-4.5
Lhloride	Kaua e kaha ake i te tohutoro whakarahi e whakamahi ana i te 2.0ml o te huka (0,025%)
Sulphate	Kaua e kaha ake i te tohutoro whakarahi e whakamahi ana i te 1.0ml o te pungatara sulphate otinga paerewa (0.05%)
Laevo isomer	NMT1.0%
Matū e pā ana	Tetahi atu poke noa: NMT0.1%
	Katoa nga poke: NMT 0.5%
Mahi	Ko te Tolterodine he kaiwhaiwhai M receptor whakataetae, a ko tana kowhiringa ki te tatai he tino kaha ake i te o te repe salivary. Ko tana aukati i te aukati i te pounamu e 20 pea nga wa o te repe salivary. I muri i te whakahaere-a-waha o te tolterodine, ko te metabolite kaha 5-hydroxymethyl derivative (DD01) i hangaia e te ate he rite ki te mahi antimuscarinic a nga matua, a, he mea nui te rongoa whakaora. He iti te hononga o nga mea e rua mo etahi atu kaiwhakawhiwhi neurotransmitter me nga whaainga pūkoro pea penei i nga waahana konupūmā.