Tolterodine Tartrate
Te Ahua | Ma te paura tioata ma ma ranei, ma te kore he kakara. |
Te wairewa | He iti nei te wairewa i te methonal, te wai waireka paku, kaore e rewa ana i te chloroform |
Wāhi rewa | 205 ~ 2 10 ºC, pirau i te wa rewa |
Te hurihanga motuhake | + 27.0º ~ + 30.0º |
Tuakiri | |
Tauhohenga matū | He rongoa te tikanga |
Te mimiti ngongo | Ka whakaatu i te rahinga nui i te 282nm |
IR | Ko te rerenga rerenga IR o te tolterodin tartrate kia rite ki tera (IR Album No.1037) o te matū tohutoro |
Tauhohenga whakaata hiriwa o te tartrate | Taapirihia he haumanu wai me nga pata waikawa hiriwa, hoatu ki roto i te pati wai me te wera, wehe te hiriwa ka piri ki te pakitara o te ngongo, he whakaata hiriwa |
Whakamatau | |
Te waikawa | PH: 3.0-4.5 |
Lhloride | Kaua e kaha ake i te tohutoro whakarahi e whakamahi ana i te 2.0ml o te huka (0,025%) |
Sulphate | Kaua e kaha ake i te tohutoro whakarahi e whakamahi ana i te 1.0ml o te pungatara sulphate otinga paerewa (0.05%) |
Laevo isomer | NMT1.0% |
Matū e pā ana | Tetahi atu poke noa: NMT0.1% |
Katoa nga poke: NMT 0.5% | |
Mahi | Ko te Tolterodine he kaiwhaiwhai M receptor whakataetae, a ko tana kowhiringa ki te tatai he tino kaha ake i te o te repe salivary. Ko tana aukati i te aukati i te pounamu e 20 pea nga wa o te repe salivary. I muri i te whakahaere-a-waha o te tolterodine, ko te metabolite kaha 5-hydroxymethyl derivative (DD01) i hangaia e te ate he rite ki te mahi antimuscarinic a nga matua, a, he mea nui te rongoa whakaora. He iti te hononga o nga mea e rua mo etahi atu kaiwhakawhiwhi neurotransmitter me nga whaainga pūkoro pea penei i nga waahana konupūmā. |
Tuhia to korero ki konei ka tuku mai ki a maatau