China Tolterodine Tartrate ifektri abakhiqizi

I-Tolterodine Tartrate

Isithombe esifakiwe se-Tolterodine Tartrate

Incazelo emfushane:

Appearance White or almost white crystalline powder ,odourless. Solubility Sparingly soluble in methonal, slightly soluble inwater, pratically insoluble in chloroform Melting point 205~ 2 10 ºC ,decomposed during the melting process Specific rotation + 27.0º~+ 30.0º Identification Chemical reaction Solution appears purpureal Characteristic absorption Exhibits a maximum at 282nm IR The IR absorption spectrum of tolterodin tartrate should concordant with that (IR Album N...

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Imininingwane yomkhiqizo

Amathegi womkhiqizo

Ukubukeka	I-powder emhlophe noma ecishe ibe mhlophe, engenaphunga.
Ukuncibilika	Incibilika kancane emanzini, encibilikayo kancane emanzini, engancibiliki kahle e-chloroform
Iphuzu lokuncibilika	205 ~ 2 10 ºC, ebolile ngesikhathi senqubo yokuncibilika
Ukujikeleza okukhethekile	+ 27.0º ~ + 30.0º
Ubunikazi
Ukusabela kwamakhemikhali	Isixazululo sivela ngamabomu
Ukumuncwa isici	Ibonisa ubuningi ku-282nm
IR	Umthamo we-IR wokumunca i-tolterodin tartrate kufanele uhambisane nalokho (IR Album No. 1037) yesethenjwa
Ukuphendula kwesibuko sesiliva kwe-tartrate	Faka i-ammonia ewuketshezi ngamaconsi esiliva e-nitrateeveral, uyibeke endaweni yokugeza yamanzi, isiliva liyazihlukanisa futhi linamathele odongeni lwangaphakathi lwe-tube, amafomu wesibuko sesiliva
Isivivinyo
I-asidi	PH: 3.0-4.5
ILhloride	Akufanele ibe namandla kakhulu kunokuxazululwa kwesethenjwa kusetshenziswa i-2.0ml yesisombululo esijwayelekile se- sodium chloride (0.025%)
Sulfate	Akufanele ibe namandla kakhulu kunokuxazululwa kwesethenjwa kusetshenziswa i-1.0ml yesisombululo esijwayelekile se- potassium sulphate (0.05%)
ILaevo isomerom	I-NMT1.0%
Izinto ezihlobene	Noma ikuphi okunye ukungcola okukodwa: NMT0.1%
	Ukungcola okuphelele: NMT 0.5%
Umsebenzi	I-Tolterodine ingumncintiswano we-M receptor antagonist, futhi ukukhetha kwayo esinyeni kunamandla amakhulu kunalokho kwendlala yamathe. Ukuvinjelwa kwaso ukusikwa kwesinye cishe izikhathi eziphindwe ka-20 kunaleyo yendlala yamathe. Ngemuva kokuphathwa ngomlomo kwe-tolterodine, i-metabolite esebenzayo ye-5-hydroxymethyl derivative (DD01) ekhiqizwa isibindi iyafana nomsebenzi wabazali we-antimuscarinic futhi inokubaluleka kokwelashwa okubalulekile. Kokubili kunokuhlangana okuncane kwamanye ama-receptor we-neurotransmitter nezinhloso ezingaba khona zamaselula ezinjengeziteshi ze-calcium.