Kina Tolterodine Tartrate hale hana a me nā mea hana

ʻO Tolterodine Tartrate

Hōʻike Pōkole:

Appearance White or almost white crystalline powder ,odourless. Solubility Sparingly soluble in methonal, slightly soluble inwater, pratically insoluble in chloroform Melting point 205~ 2 10 ºC ,decomposed during the melting process Specific rotation + 27.0º~+ 30.0º Identification Chemical reaction Solution appears purpureal Characteristic absorption Exhibits a maximum at 282nm IR The IR absorption spectrum of tolterodin tartrate should concordant with that (IR Album N...

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ʻIke kikoʻī

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Helehelena	Keʻokeʻo a ʻaneʻane keʻokeʻo crystalline pauka, ʻaʻohe onaona.
Solubility	Hiki ke hoʻoheheʻe ʻia i ka methonal, i loko o ka wai i hiki ke hoʻoheheʻe ʻia, promally insoluble i ka chloroform
Kuhi hoʻoheheʻe	205 ~ 2 10 ºC, decomposed i ke kaʻina hoʻoheheʻe
Kahi hoʻohuli	+ 27.0º ~ + 30.0º
ʻIlika
ʻLelo kemika	Kūpono ka hopena
ʻAno omo	Hōʻike i kahi palena palena ma 282nm
IR	Pono ke kikowaena o ka IR absorption o tolterodin tartrate me kēlā (IR Album No.1037) o nā mea kuhikuhi.
Ka hopena aniani kālā o ka tartrate	E hoʻohui i ka amonia wai me nā kulu nitrates kālā, kau i loko o ka waiʻauʻau andheat, dissociates kālā a hoʻopili ʻia i ka paia o ka pahu, kahi aniani kālā.
Hōʻike
ʻĀkika	PH: 3.0-4.5
Lhloride	ʻAʻole pono e ʻoi aku ka ikaika ma mua o kahi referolution e hoʻohana ana i ka 2.0ml o ka sodium chloride solution solution (0.025%)
Sulfate	ʻAʻole pono e ʻoi aku ka ikaika ma mua o kahi referolution e hoʻohana ana i ka 1.0ml o ka pāhare potassium sulphate maʻamau (0.05%)
Laevo isomer	NMT1.0%
Nā mea pili	ʻO nā haumia ʻē aʻe ʻē aʻe: NMT0.1%
	Huina impurities: NMT 0.5%
Launch	ʻO Tolterodine kahi hoʻokūkū hoʻokūkū M receptor, a ʻoi aku ka ikaika o kāna koho ʻana i ka puhū ma mua o ka momona salivary. ʻO ka pāpā ʻana o ka hoʻohaʻahaʻa bladder e pili ana i 20 mau manawa o ka salivary gland. Ma hope o ka lawelawe waha o tolterodine, ʻo ka metabolite hana nui 5-hydroxymethyl derivative (DD01) i hana ʻia e ke akepaʻa e like me ka hana antimuscarinic makua a he ʻano koʻikoʻi koʻikoʻi kona. Loaʻa ka pili liʻiliʻi o nā mea ʻelua no nā mea loaʻa nā neurotransmitter ʻē aʻe a me nā pahuhopu paʻa pūnaewele e like me nā kahawai calcium.