Tuam Tshoj Tolterodine Tartrate Hoobkas thiab tuam ntxhab

Tolterodine Tartrate

Cov lus piav qhia luv luv:

Appearance White or almost white crystalline powder ,odourless. Solubility Sparingly soluble in methonal, slightly soluble inwater, pratically insoluble in chloroform Melting point 205~ 2 10 ºC ,decomposed during the melting process Specific rotation + 27.0º~+ 30.0º Identification Chemical reaction Solution appears purpureal Characteristic absorption Exhibits a maximum at 282nm IR The IR absorption spectrum of tolterodin tartrate should concordant with that (IR Album N...

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Khoom Nthuav dav

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Tsos	Dawb lossis yuav luag dawb crystalline hmoov, ntxhiab tsw.
Tub sab	Sparingly soluble hauv methonal, me ntsis soluble inwater, pratically insoluble hauv chloroform
Melting taw tes	205 ~ 2 10 ºC, lwj hauv cov txheej txheem yaj
Kev sib hloov tshwj xeeb	+ 27.0º ~ + 30.0º
Kev Qhia Txog
Tshuaj lom neeg cov tshuaj tiv thaiv	Kev daws teeb meem purpureal tshwm sim
Cov yam ntxwv nqus	Tshaj tawm ntau ntawm 282nm
IR	IR haum spectrum ntawm tolterodin tartrate yuav tsum tau sib thooj nrog qhov ntawd (IR Album No.1037) ntawm kev siv tshuaj
Nyiaj daim iav cuam tshuam ntawm tartrate	Ntxiv cov tshuaj ammonia nrog rau cov tee ntshav nitrateseveral, muab tso rau hauv dej da dej thiab ua kom sov, nyiaj sib cais thiab txuas rau hmo ntsa ntawm lub raj, ib daim ntawv nyiaj iav
Kuaj
Ntxeev	PH: 3.0-4.5
Lhloride	Yuav tsum tsis txhob muaj qhov mob siab tshaj li qhov kev siv ntau ntxiv siv 2.0ml ntawm sodium chloride txheem tov (0.025%)
Tshav ntuj	Yuav tsum tsis txhob muaj qhov mob siab ntau dua li qhov kev siv potassium sulphate txheem tov (0.05%)
Laevo isomer	NMT1.0%
Lwm yam tshuaj yeeb dej caw	Lwm lwm qhov kev ua tsis tau ntxiv: NMT0.1%
	Tag nrho impurities: NMT 0.5%
Muaj nuj nqi	Tolterodine yog tus muaj kev sib tw M receptor antagonist, thiab nws cov neeg ua haujlwm xaiv rau lub zais zis yog qhov muaj zog ntau dua li cov kua qaub ncaug. Nws qhov kev txwv tsis pub zais zis yog kwv yees li 20 npaug ntawm uas yog mob cov qaub ncaug. Tom qab lub qhov ncauj tswj hwm ntawm tolterodine, lub ntsiab ua kom nquag plias metabolite 5-hydroxymethyl derivative (DD01) ua los ntawm daim siab yog zoo li niam txiv antimuscarinic kev ua si thiab muaj lub ntsiab lus tseem ceeb kho tau. Ob qho tib si tsis tshua muaj kev cuam tshuam rau lwm cov neurotransmitter receptors thiab cov phiaj xwm muaj peev xwm ntawm tes xws li calcium channels.