Saina Tolterodine Tartrate falegaosimea ma gaosi

Tolterodine Tartrate

Faʻamatalaga puʻupuʻu:

Appearance White or almost white crystalline powder ,odourless. Solubility Sparingly soluble in methonal, slightly soluble inwater, pratically insoluble in chloroform Melting point 205~ 2 10 ºC ,decomposed during the melting process Specific rotation + 27.0º~+ 30.0º Identification Chemical reaction Solution appears purpureal Characteristic absorption Exhibits a maximum at 282nm IR The IR absorption spectrum of tolterodin tartrate should concordant with that (IR Album N...

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Oloa Faʻamatalaga

Pine o oloa

Foliga Vaaia	Paʻepaʻe pe toeititi papaʻe crystalline paʻu, leai se manogi.
Solubility	Faʻalauteleina faʻalauteleina i methonal, laʻititi soluble i totonu o le vai, pratically insoluble i chloroform
Faaliusuavai	205 ~ 2 10 ºC, decomposed i le taimi o le liusuavai faʻagasologa
Feauauaʻiga faapitoa	+ 27.0º ~ + 30.0º
Faʻailoaina
Tali a vailaʻau	E foliga mai e lelei le fofo
Mauaina mitiia	Faʻaalia le maualuga i le 282nm
IRI	O le fusi o loʻo taliaina e le IR o tolterodin tartrate e tatau ona o gatasi ma lena (IR Album No.1037) o faʻamatalaga o vailaʻau.
Tali siliva faʻata o le tartrate	Faʻaopopo suavai amonia ma siliva nitrates soʻoso mataua, tuu i totonu o le vai taele andheat, siliva dissociates ma faʻapipiʻi i le pito i lalo puipui o le paipa, o se siliva faʻata foliga
Tofotofoga
Aseta	PH: 3.0-4.5
Lhloride	E le tatau ona sili atu le malosi nai lo le referralolution faʻaaogaina 2.0ml o le sodium chloride faʻatulagaina fofo (0.025%)
Sulphate	E le tatau ona sili atu le malosi nai lo se faʻataʻitaʻiga faʻaaogaina 1.0ml o potassium sulphate faʻataʻitaʻi fofo (0.05%)
Laevo isomer	NMT1.0%
E fesoʻotaʻi vailaʻau	Soʻo se isi lava tulaga le mama: NMT0.1%
	Aofaʻiga le mama: NMT 0.5%
Galuega tauave	Tolterodine o se tauvaga M receptor antagonist, ma o lona filifilia i le tagāmimi e sili atu le malosi nai lo lena o le salivary gland. O lona taofiina o le faapapaina o tagāmimi e tusa ma le 20 taimi nai lo le liu liu. I le maeʻa ai o le tautala tuʻuina o tolterodine, o le autu aoga metabolite 5-hydroxymethyl derivative (DD01) gaosia e le ate e tutusa ma le matua antimuscarinic gaioiga ma ei ai taua taua togafitiga. E tau leai se fealofani o tagata uma mo isi suʻesuʻega ole neurotransmitter ma ono tulimataʻi sela pei ole auala ole calcium.