Shiinaha Tolterodine warshad Tartrate iyo soosaarayaasha

Tolterodine Tartrate

Sharax Gaaban:

Appearance White or almost white crystalline powder ,odourless. Solubility Sparingly soluble in methonal, slightly soluble inwater, pratically insoluble in chloroform Melting point 205~ 2 10 ºC ,decomposed during the melting process Specific rotation + 27.0º~+ 30.0º Identification Chemical reaction Solution appears purpureal Characteristic absorption Exhibits a maximum at 282nm IR The IR absorption spectrum of tolterodin tartrate should concordant with that (IR Album N...

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Faahfaahinta alaabta

Calaamadaha alaabta

Muuqaal	Caddaan ama ku dhowaad cad budada kareemka, ur lahayn.
Xallinta	Si tartiib ah ugu milma methonal, biyaha wax yar ku milma, si aan macquul ahayn ugu milma chloroform
Barta dhalaalida	205 ~ 2 10 ºC, waa la jajabiyay inta lagu gudajiray howsha dhalaalka
Wareeg gaar ah	+ 27.0º ~ + 30.0º
Aqoonsiga
Falcelinta kiimikada	Xalku wuxuu umuuqdaa mid nadiif ah
Nuugista astaamaha	Waxay soo bandhigaan ugu badnaan 282nm
IR	Qaybta nuugista IR ee tolterodin tartrate waa inay la jaanqaaddaa taas (IR Album No.1037) oo ah walaxda tixraaca
Dareenka muraayadda qalinka ee dhalada	Ku dar ammonia dareere ah oo leh silsilado dhowr ah oo qalin ah, ku rid qubayska biyaha iyo kululeeyaha, lacagta oo kala daadata oo ku dhegta darbiga gudaha tuubada, muraayado lacag ah
Tijaabi
Acid	PH: 3.0-4.5
Lhloride	Waa inaanu ka xoog badnayn tixraac ahaan adoo adeegsanaya 2.0ml oo ah sodium chloride solution (0.025%)
Salfateeti	Ma ahan inuu ka daran yahay tixraaca xallinta iyadoo la adeegsanayo 1.0ml oo ah xalka caadiga ah ee sulphate potassium (0.05%)
Laevo isomer	NMT1.0%
Maaddooyinka la xiriira	Xumaan kasta oo kale: NMT0.1%
	Wadarta nijaasta: NMT 0.5%
Shaqaynta	Tolterodine waa la tartame ka soo horjeedka daawada M, oo xulashadeeda kaadiheysta ayaa si weyn uga xoog badan tan qanjidhada candhuufta. Xakamaynta foosha kaadiheysta waxay kudhowaad 20 jeer ka tahay qanjidhada candhuufta. Maamulka afka kadib ee tolterodine, metabolit-ka ugu weyn ee firfircoon 5-hydroxymethyl derivative (DD01) ee ay soo saarto beerku wuxuu lamid yahay waxqabadka antimuscarinic ee waalidka wuxuuna leeyahay muhiimad daweyn. Labaduba waxay leeyihiin xidhiidh aan badnayn oo loogu talagalay kuwa soo dhaweeyayaasha neurotransmitter-ka iyo bartilmaameedyada gacanta ee suurtogalka ah sida kanaalada kalsiyum.