China Tolterodine Tartrate mveliso kunye nabenzi

I-Tolterodine iTartrate

Umfanekiso obonisiweyo weTolterodine Tartrate

Inkcazo emfutshane:

Appearance White or almost white crystalline powder ,odourless. Solubility Sparingly soluble in methonal, slightly soluble inwater, pratically insoluble in chloroform Melting point 205~ 2 10 ºC ,decomposed during the melting process Specific rotation + 27.0º~+ 30.0º Identification Chemical reaction Solution appears purpureal Characteristic absorption Exhibits a maximum at 282nm IR The IR absorption spectrum of tolterodin tartrate should concordant with that (IR Album N...

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Iinkcukacha Product

Iimpawu zemveliso

Inkangeleko	I-powder emhlophe okanye emhlophe emhlophe, engenavumba.
Ukunyibilika	Ukunyibilika kancinci kwimethonal, enyibilikayo kancinci emanzini, enganyibilikiyo kwi-chloroform
Indawo yokunyibilika	205 ~ 2 10 ºC, ebolile ngexesha lenkqubo yokunyibilika
Ujikelezo oluthile	+ 27.0º ~ + 30.0º
Ukuchonga i-
Ukuphendula ngamachiza	Isisombululo sivela ngenjongo
Ukufakwa kwezinto	Ibonisa ubuninzi kwi-282nm
IR	Ubume bokufakwa kwe-IR kwitolterodin tartrate kufuneka buhambisane naleyo (ye-IR ye-Nombolo ye-1037) yesalathiso sezinto
Ukuphendula kwesipili kwesilivere kwetartrate	Yongeza i-ammonia engamanzi ngeesilitha ze-nitrate, amathontsi, uwafake kwindawo yokuhlambela amanzi kunye neshushu, isilivere iyahlukana kwaye inamathele kudonga lwangaphakathi lombhobho, iifom zesilivere zesilivere
Uvavanyo
Ubumuncu	PH: 3.0-4.5
ILloride	Akufuneki ibe namandla ngakumbi kunesisombululo sokubhekisa usebenzisa i-2.0ml yesisombululo esimiselweyo sesodium chloride (0.025%)
Sulphate	Akufuneki ibe namandla ngakumbi kunesisombululo sereferensi usebenzisa i-1.0ml yesisombululo se potassium sulphate (0.05%)
Laevo isomerom	I-NMT1.0%
Izinto ezinxulumene noko	Nakuphi na ukungcola okukodwa: NMT0.1%
	Ukungcola kuphelele: NMT 0.5%
Umsebenzi	I-Tolterodine kukhuphiswano lwe-M receptor antagonist, kunye nokukhetha kwayo kwisinyi kunamandla kakhulu kunalawo e-salivary gland. Uthintelo lwayo lwesinyi esinyinyithekileyo lumalunga namaxesha angama-20 kwincindi yamathe. Emva kolawulo lomlomo lwe-tolterodine, eyona nto iphambili isuselwe kwimetabolite ye-5-hydroxymethyl derivative (DD01) eveliswe sisibindi iyafana nomsebenzi we-antimuscarinic yabazali kwaye inokubaluleka kokunyanga. Zombini zinobudlelwane obuncinci kwezinye ii-receptors ze-neurotransmitter kunye neethagethi ezinokubakho zeselfowuni ezinje ngemijelo yecalcium.