China Tolterodine Tartrate fekitari uye vagadziri

Tolterodine Tartrate

Tsananguro Pfupi:

Appearance White or almost white crystalline powder ,odourless. Solubility Sparingly soluble in methonal, slightly soluble inwater, pratically insoluble in chloroform Melting point 205~ 2 10 ºC ,decomposed during the melting process Specific rotation + 27.0º~+ 30.0º Identification Chemical reaction Solution appears purpureal Characteristic absorption Exhibits a maximum at 282nm IR The IR absorption spectrum of tolterodin tartrate should concordant with that (IR Album N...

Tumira neindaneti kwatiri Dhawunirodha sePDF

Chigadzirwa Chigadzirwa

Chigadzirwa Mateki

Chitarisiko	Yakachena kana ingangoita chena yekristaro poda, isina kunhuwa.
Solubility	Kashoma kusungunuka mu methonal, zvishoma kusungunuka mukati memvura, pratically insoluble mu chloroform
Nzvimbo yakanyunguduka	205 ~ 2 10 ºC, yakaora panguva yekunyungudika
Chaicho kutenderera	+ 27.0º ~ + 30.0º
Chitupa
Chemical kuita	Mhinduro inoratidzika kunge ine chinangwa
Mamirire Absorção de .gua	Inoratidzira yakakwira pa282nm
IR	Iyo IR yekumwa spectrum ye tolterodin tartrate inofanirwa kuenderana neiyo (IR Album Nha. 1037) yechinongedzo chinhu
Sirivheri girazi maitiro e tartrate	Wedzera mvura ammonia ine sirivheri nitrateeveral madonhwe, iise mukati mekugezesa mvura uye kupisa, sirivheri inoparadzanisa uye inosungira kune yemukati madziro ehubhu, sirivheri girazi mafomu
Bvunzo
Acidity	PH: 3.0-4.5
Lhloride	Hazvifanire kunyanyisa kupfuura chirevo chinogadziriswa chinoshandisa 2.0ml yesodium chloride standard solution (0.025%)
Sulfate	Hazvifanire kunyanyisa kupfuura chirevo chekugadzirisa uchishandisa 1.0ml ye potassium sulphate standard solution (0.05%)
Laevo isomer	NMT1.0%
Zvinoenderana nezvinhu	Chero kumwe kusachena kumwe chete: NMT0.1%
	Kusviba kwese: NMT 0.5%
Rinoshanda	Tolterodine inokwikwidza M receptor antagonist, uye kwayo kusarudza kune dundira kwakasimba zvakanyanya kupfuura kweiyo salivary gland. Kuvhiringidza kwaro kudzvinyirira kwechironda kwakapetwa ka makumi maviri pane cheganda rematehwe. Mushure mekutaurwa kwemuromo kwetolterodine, iyo inoshingairira metabolite 5-hydroxymethyl derivative (DD01) inogadzirwa nechiropa yakafanana neyevabereki antimuscarinic chiitiko uye ine yakakosha yekurapa kukosha. Ose ari maviri ane hukama hwediki kune mamwe maurotransmitter receptors uye zvingangoita nhare dzemaseru senge calcium chiteshi.