Pabrik Tartrate Tolterodine Cina lan pabrikan

Tolterodine Tartrate

Katrangan singkat:

Appearance White or almost white crystalline powder ,odourless. Solubility Sparingly soluble in methonal, slightly soluble inwater, pratically insoluble in chloroform Melting point 205~ 2 10 ºC ,decomposed during the melting process Specific rotation + 27.0º~+ 30.0º Identification Chemical reaction Solution appears purpureal Characteristic absorption Exhibits a maximum at 282nm IR The IR absorption spectrum of tolterodin tartrate should concordant with that (IR Album N...

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Detail Produk

Tag Produk

Penampilan	Bubuk kristal putih utawa meh putih, ora ana ambu.
Kelarutan	Larut larut ing banyu ing banyu methonal, rada larut, ora larut ing kloroform
Titik lebur	205 ~ 2 10 ºC, diurai sajrone proses leleh
Rotasi tartamtu	+ 27.0º ~ + 30.0º
Identifikasi
Reaksi kimia	Solusi katon sengaja
Penyerapan karakteristik	Pameran maksimum ing 282nm
IR	Spektrum penyerapan IR tartter tolterodin kudu cocog karo (referensi IR Album No.1037)
Reaksi pangilon perak saka tartrat	Tambah amonia cair nganggo irungnya nitrates perak, lebokake ing adus banyu lan panas, salaka disosiasi lan dipasang ing tembok tabung, kaca spion perak
Tes
Asam	PH: 3.0-4.5
Klorida	Apa ora luwih kuat tinimbang referensi sing nggunakake 2,0 ml larutan standar natrium klorida (0,025%)
Sulfat	Apa ora luwih kuat tinimbang referensi sing nggunakake (0,05%)
Laevo isomer	NMT1.0%
Bahan sing gegandhengan	Impurity tunggal liyane: NMT0.1%
	Total impurities: NMT 0,5%
Fungsi	Tolterodine minangka antagonis reseptor M sing kompetitif, lan pilih kandhungan kandung kemih luwih kuwat tinimbang kelenjar ludah. Nyandhet kontraksi kandung kemih udakara 20 kali tinimbang kelenjar ludah. Sawise administrasi oral tolterodine, turunan metabolit aktif 5-hidroksiametil (DD01) sing diasilake dening ati padha karo kegiyatan antimuscarinic saka wong tuwa lan nduweni teges terapi sing signifikan. Loro-lorone duwe afinitas cilik kanggo reseptor neurotransmitter liyane lan target target seluler kaya saluran kalsium.