China Famotidine ifektri abakhiqizi

I-Famotidine

Incazelo emfushane:

Appearance White to pale yellowish-white crystalline powder Solubility Freely soluble in dimethylform-amide and in glacial acetic acid; slightly soluble in methanol; very slightly soluble in water; practically insoluble in acetone, in alcohol, in chloroform, in ether, and in ethyl acetate. Identification IR Absorption: Consist with the spectra obtained with Famotidine CRS. Related Substance Related compound B ≤0.3% Related compound C ≤0.3% Related compound D ≤0.3% Re...

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Imininingwane yomkhiqizo

Amathegi womkhiqizo

Ukubukeka	I-powder emhlophe ephuzi emhlophe ephuzi
Ukuncibilika	Kuncibilika ngokukhululeka ku-dimethylform-amide naku-glacial acetic acid; encibilika kancane ku-methanol; kuncibilika kancane emanzini; cishe kungancibiliki ku-acetone, otshwaleni, ku-chloroform, ku-ether naku-ethyl acetate.
Ubunikazi	Ukumunca i-IR:
Ubunikazi	Ihambisana nombukiso otholwe nge-Famotidine CRS.
Okuhlobene	Inhlanganisela ehlobene B ≤0.3%
	Inhlanganisela ehlobene C ≤0.3%
	Inhlanganisela ehlobene D ≤0.3%
	Inhlanganisela ehlobene E -0.3%
	Inhlanganisela ehlobene F ≤0.1%
	ICyanoamidine ≤0.2%
	I-Amidine ≤0.2%
	Noma yikuphi ukungcola komuntu ngamunye ≤0.1%
	Ukungcola okuphelele≤ 1.0%
Ukulahlekelwa Kokomiswa	≤0.5%
Okusalile ku-Ignition	≤0.1%
Izinsimbi ezisindayo	P10ppm
Izincibilikisi ezisele	I-Ethanol≤0.5%
Izincibilikisi ezisele	I-Acetone≤0.5%
Assay	.598.5%
Umsebenzi	Iqukethe indandatho ye-thiazole futhi inethonya elinamandla lokuvimbela uketshezi lwe-gastric acid. Ubude besenzo bude kakhulu kulesi sigaba semithi. Ayikho i-anti-androgen kanye nokuvimbela ama-enzyme we-metabolic. I-Famotidine ingavimbela kakhulu ukwehliswa kokuqukethwe kwe-glycoprotein ku-mucosa yesisu yamagundane abangelwa yingcindezi, futhi ukuphathwa okuqhubekayo kungakhuthaza ukuphulukiswa kwezilonda ezingamahlalakhona. Ukuhlolwa okuphambene okungaboni kabili ekuhlolweni kwezilwane nasekliniki okuphuma ukopha emathunjini kubonise ukuthi i-famotidine inomphumela we-hemostatic. Lo mkhiqizo unomphumela wokuvikela ukulimala kwe-mucosal esiswini sokuhlola nokwanda kokuhamba kwegazi kwe-mucosa yesisu. Lo mkhiqizo awushintshi isilinganiso sokukhishwa kwesisu, awuphazamisi ukusebenza kwe-pancreatic, akukho teratogenic, carcinogenic, ukuvinjelwa kwama-enzyme wezidakamizwa zesibindi nokuvimbela i-androgen.