China ifototidine mveliso kunye nabenzi

Famotidine

Inkcazo emfutshane:

Appearance White to pale yellowish-white crystalline powder Solubility Freely soluble in dimethylform-amide and in glacial acetic acid; slightly soluble in methanol; very slightly soluble in water; practically insoluble in acetone, in alcohol, in chloroform, in ether, and in ethyl acetate. Identification IR Absorption: Consist with the spectra obtained with Famotidine CRS. Related Substance Related compound B ≤0.3% Related compound C ≤0.3% Related compound D ≤0.3% Re...

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Iinkcukacha Product

Iimpawu zemveliso

Inkangeleko	Mhlophe ukuba ngumthubi omhlophe tyheli-mhlophe umgubo
Ukunyibilika	Isinyibilikisi ngokukhululekileyo kwi-dimethylform-amide nakwi-glacial acetic acid; inyibilike kancinci kwimethanol; inyibilike kancinci emanzini; ngokungenakunyibilika kwi-acetone, etywaleni, kwi-chloroform, kwi-ether nakwi-ethyl acetate.
Ukuchonga i-	Ukufakwa kwe-IR:
Ukuchonga i-	Ngokuhambelana nembonakalo efumaneka kwi-Famotidine CRS.
Iziyobisi ezinxulumene noko	Ikhompawundi ehambelana nayo B -0.3%
	Ikhompawundi ehambelana nayo C -0.3%
	Ikhompiyutha ehambelana nayo ≤0.3%
	Ikhompawundi ehambelana nayo E -0.3%
	Ikhomputha ehambelanayo F -0.1%
	ICyanoamidine ≤0.2%
	Amidine ≤0.2%
	Nakuphi na ukungcola komntu ngamnye ≤0.1%
	Ukungahlambuluki okupheleleyo
Ilahleko ekomiseni	≤0.5%
Intsalela kucinezelo	≤0.1%
Isinyithi esinzima	10ppm
Isinyibilikisi sentsalela	I-ethanol≤0.5%
Isinyibilikisi sentsalela	I-Acetone≤0.5%
Uvavanyo	.598.5%
Umsebenzi	Iqulethe umsesane we-thiazole kwaye inefuthe elinamandla lokuthintela ukufihlwa kwesisu esiswini. Ixesha lesenzo lelona lide kule klasi yeziyobisi. Akukho anti-androgen kunye nokuthintela ii-enzymes zemetabolic. I-Famotidine inokuthintela ngokubonakalayo ukunciphisa umxholo we-glycoprotein kwi-gastric mucosa yeempuku ezibangelwa luxinzelelo, kunye nolawulo oluqhubekayo lunokukhuthaza ukuphiliswa kwezilonda ezingapheliyo. Uvavanyo olwahluke kabini oluyimfama kuvavanyo lwezilwanyana kunye nonyango oluphuma phezulu emathunjini lubonise ukuba i-famotidine inefuthe lobunzima. Le mveliso ineziphumo zokukhusela ulingo lomonakalo wesisu esiswini kunye nokwanda kokuhamba kwegazi kwetyhefu yesisu. Le mveliso ayitshintshi inqanaba lesisu esiswini, ayiphazamisi ukusebenza kwepancreatic, akukho teratogenic, carcinogenic, inhibition ye-enzyme yeziyobisi zesibindi kunye nokuthintela i-androgen.