I-Rifampicin (Rifaximin), etholakala nge-rifamycin, yasungulwa yi-Alfa Italy. Ithengiswe e-Italy njengesidakamizwa sohudo esilwa nokutheleleka ngo-1987 futhi sisasetshenziswa kabanzi phesheya. Kuvunyelwe yi-SFDA e2004, isetshenzisiwe ekwenzeni imitholampilo eChina. Kuyisidakamizwa se-rifamycin semi-synthetic antibacterial. Ine-spectrum ebanzi elwa namagciwane nomsebenzi onamandla wokulwa namagciwane. Kungakha ukuhlangana okuphezulu kwegazi emgodini wamathumbu. Ingavimbela iStaphylococcus aureus, iStreptococcus faecalis ne-Salmonella kuma-aerobes ane-gram-positive, angaphansi kohlobo lwe-Salmonella kumabhaktheriya we-Gram-negative aerobic. IShigella ne-Escherichia coli, i-Yersinia enterocolitica kanye ne-Gram-positive anaerobic bacteria onke anomsebenzi ophezulu wokulwa namagciwane. Indlela yokusebenza kwayo ukuvimbela i-bacterial polymerase, ukuvimba inqubo yokubhalwa kwe-RNA, bese kuvimbela ukuhlanganiswa kwamaprotheni wegciwane, ngaleyo ndlela kunciphise ukukhiqizwa kwe-ammonia. 1) umsebenzi wokulwa namagciwane unamandla, futhi i-spectrum elwa namagciwane ibanzi. Inomphumela wamagciwane kuma-bacterium amaningi ane-gram-positive kanye ne-gram-negative bacteria (kufaka phakathi amabhaktheriya e-aerobic kanye nama-bacterial anaerobic), futhi umphumela kuma-bacterium ane-gram unamandla kunalowo kuma-bacteria angenayo i-gram-negative. I-2) ayifunxwa umgudu wamathumbu, futhi ukugxila kwayo kuphezulu kakhulu emathunjini emathumbu. Ingabulala igciwane lesandulela ngculaza emathunjini futhi idlale nomphumela wokulwa namagciwane ngokushesha endaweni yasendaweni, futhi akudingekile ukusebenzisa izidakamizwa ze-antispasmodic kanye ne-adsorptive zihlangene nomgudu wamathumbu.