Rifampicin (Rifaximin), chochokera ku rifamycin, idapangidwa ndi Alfa Italy. Anagulitsidwa ku Italy ngati mankhwala otsekula m'mimba mu 1987 ndipo akugwiritsidwabe ntchito kunja. Yavomerezedwa ndi SFDA mu 2004, idagwiritsidwa ntchito ngati zamankhwala ku China. Ndi mankhwala opha tizilombo a rifamycin. Ili ndi sipekitiramu yayikulu yama antibacterial komanso yolimba yoletsa antibacterial. Itha kupanga magazi ochulukirapo m'matumbo. Ikhoza kuletsa Staphylococcus aureus, Streptococcus faecalis ndi Salmonella mu gram-positive aerobes, omwe ali amtundu wa Salmonella m'mabakiteriya a Gram-negative aerobic. Shigella ndi Escherichia coli, Yersinia enterocolitica ndi mabakiteriya a gram-positive anaerobic onse ali ndi ma antibacterial. Njira yogwiritsira ntchito ndikuletsa bakiteriya polymerase, kutseka njira yolembera ya RNA, kenako ndikuletsa kaphatikizidwe ka mapuloteni a bakiteriya, motero kumachepetsa ammonia. 1) ntchito ya antibacterial ndiyolimba, ndipo mawonekedwe a antibacterial ndi otakata. Amakhala ndi bactericidal ku mabakiteriya ambiri omwe ali ndi gramu ndi mabakiteriya omwe alibe gramu (kuphatikiza mabakiteriya a aerobic ndi mabakiteriya a anaerobic), ndipo zomwe zimachititsa mabakiteriya omwe ali ndi gram ndiyolimba kuposa mabakiteriya omwe alibe magalamu. 2) sichimadzilowetsa m'matumbo, ndipo ndende yake imakhala yayikulu kwambiri m'matumbo. Itha kupha tizilombo toyambitsa matenda m'matumbo ndikusewera ndi mabakiteriya mwachangu m'deralo, ndipo sikoyenera kugwiritsa ntchito mankhwala opatsirana pogonana komanso ojambulira limodzi ndi matumbo.