Vitamin C, ti a tun mọ ni ascorbic acid, jẹ eroja pataki ti omi-tiotuka. Awọn eniyan ati diẹ ninu awọn ẹranko miiran (bii awọn alakọbẹrẹ, awọn elede) da lori Vitamin C ninu ipese ounjẹ ti awọn eso ati ẹfọ (ata pupa, ọsan, eso didun kan, broccoli, mango, lemon). Iṣe agbara ti Vitamin C ni idena ati imudarasi awọn akoran ni a ti mọ ni agbegbe iṣoogun.
Ascorbic acid jẹ pataki fun idahun ajesara. O ni egboogi-iredodo pataki, imunomodulatory, antioxidant, egboogi-thrombosis ati awọn ohun-ini egboogi-gbogun.
Vitamin C seems to be able to regulate the host's response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus is the causative factor of the 2019 coronavirus disease (COVID-19) pandemic, especially It is in a critical period. In a recent comment published in Preprints*, Patrick Holford et al. Solved the role of vitamin C as an auxiliary treatment for respiratory infections, sepsis and COVID-19.
Nkan yii jiroro ipa ti o pọju ti Vitamin C ni idilọwọ ipele pataki ti COVID-19, awọn akoran atẹgun nla ati awọn aisan aiṣan miiran. A nireti pe ifunni Vitamin C lati jẹ ajesara tabi oluranlowo itọju fun awọn aiṣedede atunse COVID-19 ti o fa nipasẹ arun, idinku iyọkuro ọfun, imudarasi iṣelọpọ interferon ati atilẹyin awọn ipa egboogi-iredodo ti awọn glucocorticoids.
Lati le ṣetọju awọn ipele pilasima deede ninu awọn agbalagba ni 50 µmol / l, iwọn Vitamin C fun awọn ọkunrin jẹ 90 mg / d ati fun awọn obinrin 80 mg / d. Eyi to lati ṣe idiwọ scurvy (arun ti o ṣẹlẹ nipasẹ aini Vitamin C). Sibẹsibẹ, ipele yii ko to lati ṣe idiwọ ifihan gbogun ti ati apọju ti ẹkọ-ara.
Therefore, the Swiss Nutrition Society recommends supplementing each person with 200 mg of vitamin C-to fill the nutritional gap of the general population, especially adults 65 years and older. This supplement is designed to strengthen the immune system. "
Labẹ awọn ipo apọju ti ẹkọ iwulo ara, awọn ipele Vitamin C eniyan silẹ silẹ ni iyara. Akoonu omi ara Vitamin C ti awọn alaisan ile-iwosan jẹ ≤11µmol / l, ati pe ọpọlọpọ ninu wọn jiya lati ikolu atẹgun nla, sepsis tabi COVID-19 ti o le koko.
Orisirisi awọn iwadii ọran lati kakiri agbaye tọka pe awọn ipele Vitamin C kekere jẹ wọpọ ni awọn alaisan ile iwosan ti o nira pupọ pẹlu awọn akoran atẹgun, poniaonia, sepsis ati COVID-19-alaye ti o ṣeese julọ ni alekun agbara ijẹ-ara.
Atọjade-meta ṣe afihan awọn akiyesi atẹle: 1) Afikun Vitamin C le dinku eewu ti ẹdọfóró ni pataki, 2) Awọn iwadii ifiweranṣẹ lẹhin iku lẹhin iku lati COVID-19 fihan aarun ọgbẹ keji, ati 3) Aito Vitamin C jẹ iṣiro fun apapọ olugbe pẹlu ẹdọfóró 62%.
Vitamin C ni ipa ipa homeostatic pataki bi antioxidant. O mọ lati ni iṣẹ ṣiṣe pipa ọlọjẹ taara ati pe o le mu iṣelọpọ ti interferon pọ si. O ni awọn ilana ṣiṣe ni ọna mejeeji ati awọn eto apọju adaptive. Vitamin C dinku awọn eefun atẹgun ifaseyin (ROS) ati iredodo nipa didin imuṣiṣẹ ti NF-κB sii.
SARS-CoV-2 down-regulates the expression of type 1 interferon (the host's main antiviral defense mechanism), while ascorbic acid up-regulates these key host defense proteins.
Apakan pataki ti COVID-19 (igbagbogbo apaniyan apaniyan) waye lakoko iṣafihan apọju ti awọn cytokines pro-inflammatory ti o munadoko ati awọn chemokines. Eyi yori si idagbasoke ikuna eto ara ọpọ. O ni ibatan si ijira ati ikojọpọ ti awọn neutrophils ninu interstitium ti ẹdọfóró ati iho bronchoalveolar, igbehin jẹ ipinnu bọtini ti ARDS (Arun Inu Ẹjẹ Atẹgun Aisan).
Ifojusi ti ascorbic acid ninu awọn keekeke ti o wa ni ọfun ati pituitary jẹ igba mẹta si mẹwa ti o ga ju ni eyikeyi eto ara miiran lọ. Labẹ aibanujẹ ti ẹkọ iwulo ẹya (iwunilori ACTH) awọn ipo pẹlu iṣafihan gbogun ti ara, Vitamin C ti ni itusilẹ lati kotesi adrenal, ti o n fa awọn ipele pilasima lati pọ si ni ilọpo marun.
Vitamin C le ṣe alekun iṣelọpọ ti cortisol, ati mu ki egboogi-iredodo ati awọn ipa aabo cell endothelial ti awọn glucocorticoids. Awọn sitẹriọdu glucocorticoid Exogenous nikan ni awọn oogun ti o ti jẹri lati tọju COVID-19. Vitamin C jẹ homonu oniruru-ipa ti ọpọlọpọ-ipa, eyiti o ṣe ipa pataki ninu ilaja idahun wahala wahala kotesi adrenal (paapaa sepsis) ati aabo endothelium lati ibajẹ ọgbẹ.
Mu sinu ipa ti Vitamin C lori awọn otutu-dinku akoko, ibajẹ ati igbohunsafẹfẹ ti otutu-mu Vitamin C le dinku iyipada lati inu irẹlẹ ọlọjẹ si akoko pataki ti COVID-19.
A ti ṣakiyesi pe ifikun Vitamin C le fa kuru gigun ti iduro ni ICU, fa kikuru akoko fentilesonu ti awọn alaisan ti o ni aisan nla pẹlu COVID-19, ati dinku oṣuwọn iku ti awọn alaisan sepsis ti o nilo itọju pẹlu vasopressors.
Ti ṣe akiyesi awọn ipo pupọ ti igbẹ gbuuru, awọn okuta kidinrin ati ikuna kidirin lakoko awọn abere giga, awọn onkọwe jiroro aabo ti ẹnu ati iṣakoso iṣọn-ẹjẹ ti Vitamin C. A le ṣe iṣeduro iwọn lilo igba kukuru to ni aabo ti 2-8 g / ọjọ ṣọra yago fun awọn abere giga fun awọn eniyan ti o ni itan-akọọlẹ ti awọn okuta kidinrin tabi arun aisan). Nitori pe o jẹ tiotuka-omi, o le yọkuro laarin awọn wakati diẹ, nitorinaa igbohunsafẹfẹ doseji ṣe pataki lati ṣetọju awọn ipele ẹjẹ to pe lakoko ikolu ti nṣiṣe lọwọ.
Bi gbogbo wa ṣe mọ, Vitamin C le ṣe idiwọ ikolu ati mu ilọsiwaju esi. Paapa ti o tọka si ipele pataki ti COVID-19, Vitamin C ṣe ipa pataki. O sọkalẹ-ṣe iṣakoso iji cytokine, ṣe aabo endothelium lati ibajẹ ifoyina, yoo ṣe ipa pataki ninu atunṣe àsopọ, ati imudarasi idahun ajesara si ikolu.
Onkọwe ṣe iṣeduro pe awọn afikun Vitamin C yẹ ki o ṣafikun ni gbogbo ọjọ lati ṣe iwuri fun awọn ẹgbẹ ti o ni eewu giga pẹlu iku COVID-19 giga ati aipe Vitamin C. Wọn yẹ ki o rii daju nigbagbogbo pe Vitamin C jẹ deede ati mu iwọn lilo pọ si nigbati ọlọjẹ naa ba ni akoso, to 6-8 g / ọjọ. Nọmba ti awọn ikẹkọ ẹgbẹ Vitamin C ti o gbẹkẹle iwọn lilo jẹ ti nlọ lọwọ kariaye lati jẹrisi ipa rẹ ninu imukuro COVID-19 ati lati ni oye daradara ipa rẹ bi agbara itọju.
Awọn preprints yoo ṣe agbejade awọn iroyin ijinle sayensi akọkọ ti a ko ti ṣe atunyẹwo ẹlẹgbẹ, nitorinaa ko yẹ ki o ṣe akiyesi pe o pari, didari iṣe iṣoogun / awọn ihuwasi ti o jọmọ ilera tabi ka alaye alaye to daju.
Awọn afi: ailera aarun ibanujẹ nla, egboogi-iredodo, antioxidant, ascorbic acid, ẹjẹ, broccoli, chemokine, coronavirus, arun coronavirus COVID-19, corticosteroid, cortisol, cytokine, cytokine, gbuuru, igbohunsafẹfẹ, Glucocorticoids, homonu, ajẹsara ajẹsara, ajesara eto, iredodo, interstitial, kidirin, arun akọn, ikuna kidinrin, iku, ounjẹ, aapọn ipanilara, ajakaye-arun, ọgbẹ-ara, atẹgun, SARS-CoV-2, scurvy, Sepsis, arun atẹgun nla ti o lagbara, aarun atẹgun nla ti o lagbara, iru eso didun kan, wahala , ailera, ẹfọ, ọlọjẹ, Vitamin C
Ramya ni oye PhD. Pune National Chemical Laboratory (CSIR-NCL) gba Ojúgbà ninu Biotechnology. Iṣẹ rẹ pẹlu ṣiṣiṣẹ awọn ẹwẹ titobi pẹlu awọn molikula oriṣiriṣi ti anfani ti ara, keko awọn ọna ṣiṣe ihuwasi ati kikọ awọn ohun elo to wulo.
Dwivedi, Ramya. (2020, Oṣu Kẹwa Ọjọ 23). Vitamin C ati COVID-19: Atunwo kan. Iṣoogun iroyin. Ti gba wọle lati https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx ni Oṣu kọkanla 12, 2020.
Dwivedi, Ramya. "Vitamin C and COVID-19: A Review." News medical. November 12, 2020. .
Dwivedi, Ramya. "Vitamin C and COVID-19: A Review." News medical. https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx. (Accessed on November 12, 2020).
Dwivedi, Ramya. 2020. "Vitamin C and COVID-19: A Review." News-Medical, browsed on November 12, 2020, https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx.
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