Vitamini C, e taʻua foi ole ascorbic acid, ose mea taua e mafai ona sua ile vai. O tagata ma isi meaola (pei o primates, puaa) e faʻamoemoe i le vaitamini C i le sapalaiina o meaʻai ma fualaʻau (mumu pepa, moli, strawberry, broccoli, mango, lemoni). O le aoga i le vailaʻau C i le puipuia ma le faʻaleleia atili o faʻamaʻi ua iloa i le fomaʻi.
Ascorbic acid e taua mo le tali atu ile puipuiga. E i ai taua taua anti-afaina, immunomodulatory, antioxidant, aneti-thrombosis ma aneti-viral meatotino.
Vitamin C seems to be able to regulate the host's response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus is the causative factor of the 2019 coronavirus disease (COVID-19) pandemic, especially It is in a critical period. In a recent comment published in Preprints*, Patrick Holford et al. Solved the role of vitamin C as an auxiliary treatment for respiratory infections, sepsis and COVID-19.
O lenei tusitusiga o loʻo talanoaina ai le ono iai o le vaitamini C i le puipuia o le tulaga taua o le COVID-19, o faʻamaʻi pipisi o respiratory respiratory ma isi faʻamaʻi pipisi. Vitamini faʻaopoopoga C e faʻamoemoe e avea ma puipuia poʻo se vailaʻau sui mo COVID-19-faʻasaʻoina faʻaletonu mafua mai le faʻamaʻi, faʻaititia le faʻamalosia o le oxidative, faʻalauteleina interferon gaosiga ma lagolagoina le teteʻe-afaina aʻafiaga o glucocorticoids.
Ina ia faʻatumauina tulaga masani o le plasma i tagata matutua i le 50 µmol / l, o le vailaʻau C fualaʻau mo aliʻi e 90 mg / d ma mo fafine 80 mg / d. Ua lava lea e puipuia ai le scurvy (o se faʻamaʻi e mafua mai i le le lava o vitamini C). Ae ui i lea, o lenei tulaga e le lava e puipuia ai le faʻalauiloaina o siama ma faʻafitauli o le tino.
Therefore, the Swiss Nutrition Society recommends supplementing each person with 200 mg of vitamin C-to fill the nutritional gap of the general population, especially adults 65 years and older. This supplement is designed to strengthen the immune system. "
I lalo ole faʻamalosi tino, e vave lava ona paʻu le suka vitamini C. O le vailaʻau o le vitamini C o loʻo i totonu o le falemaʻi o le ≤11µmol / l, ma o le toʻatele o latou e pagatia i le papala o le respiratory respiratory, sepsis poʻo le COVID-19 ogaoga.
Eseese mataupu suʻesuʻega mai le salafa o le lalolagi faʻailoa mai ai o le maualalo o le vailaʻau C tulaga e masani ai i tagata mamaʻi tigaina i falemaʻi ma faʻamaʻi manava, papemonia, sepsis ma COVID-19-o le ono ono faʻamatalaga o le faʻateleina metabolic taumafaina.
O le suʻesuʻega faʻapitoa na faʻamamafaina ai mea nei: 1) O le faʻaopoopoga o le Vitamini C e mafai ona faʻaititia ai le ono maua i le niumonia, 2) O suʻesuʻega pe a maeʻa le maliu mai le COVID-19, na faʻaalia ai le maualalo o le niumonia, ma le 3) O le le lava o le Vitamini C na maua ai le aofaʻi o tagata niumonia 62%.
Vitamini C ei ai lona taua homeostatic aafiaga o se antioxidant. E iloa e iai saʻo le fasioti o siama ma e mafai ona faʻateleina le gaosia o le interferon. E i ai effector faiga i totonu o le natura ma fetuutuunai puipuiga puipuia. Vitamini C faʻaititia reactive okesene ituaiga (ROS) ma pupuga i le faʻaititia o le faʻagaina o le NF-κB.
SARS-CoV-2 down-regulates the expression of type 1 interferon (the host's main antiviral defense mechanism), while ascorbic acid up-regulates these key host defense proteins.
O le taua vaega o COVID-19 (masani lava o le afaina vaega) tupu i le taimi o le soona gaosia o lelei pro-inflammatory cytokines ma chemokines. O lenei mea na mafua ai le atinaʻeina o le tele o totoga na le manuia. E fesoʻotaʻi ma le femalagaaʻi ma le faʻaputuputuina o neutrophil i totonu o le mama interstitium ma le bronchoalveolar ana, o le mulimuli o se autu autu o ARDS (Acute Respiratory Distress Syndrome).
O le faʻasalaga o ascorbic acid i totonu o adrenal glands ma pituitary gland e tolu i le sefulu taimi maualuga atu nai lo se isi lava totoga. I lalo o le faʻamalosi tino (ACTH stimulate) tuutuuga e aofia ai faʻamaʻi viral, vitamini C ua faʻasaʻoloto mai le adrenal cortex, mafua ai le maualuga o le toto faʻateleina lima.
Vitamini C mafai faʻalauteleina le gaosiga o le cortisol, ma faʻalauteleina le anti-afaina ma endothelial sela puipuiga aafiaga o glucocorticoids. O Exogenous glucocorticoid steroids e naʻo le pau ia o vailaʻau ua faʻamaonia e togafitia ai le COVID-19. Vitamini C o le tele-aafiaga faʻamalosia homone, lea e taua tele i le faʻatalanoaina o le adrenal cortex popole tali (aemaise sepsis) ma puipuia le endothelium mai oxidative faʻaleagaina.
I le amanaʻia ai o le aʻafiaga o le vaitamini C i luga o malulu-e faʻaititia ai le umi, ogaoga ma le tele o le maʻalili e maua ai le vaitamini C, e mafai ona faʻaititia ai le suiga mai siama mama i le vaitaimi faigata o le COVID-19.
Ua maitauina o le vaitamini C faʻaopoopoga e mafai ona faʻapuʻupuʻuina le umi o le nofo ai i le ICU, faʻapuʻupuʻu le taimi e faʻaavanoaina ai gasegase tigaina ma le COVID-19, ma faʻaititia ai le tulaga o tagata feoti sepsis o loʻo manaʻomia togafitiga ma vasopressors.
I le amanaia ai o tuutuuga eseese o manava tatā, fatugaʻo maʻa ma le fatugaʻo tisaini i le maualuga o tui, na talanoaina ai e tusitala le saogalemu o le tautala ma faʻaaoga totonu o vaitamini C. O se saogalemu puʻupuʻu maualuga maualuga fualaʻau o le 2-8 g / aso e mafai ona fautuaina ( 'alofia ma le faʻaeteete maualuga togi mo tagata e iai le talaʻaga o maʻa fatu poʻo faʻamaʻi fatugaʻo). Talu ai e mafai ona faʻavaivaia i le vai, e mafai ona faʻaalu i fafo i totonu o ni nai itula, o lona uiga la, e taua le fuatele mai o le suka e faʻatumau ai le lava o le toto i taimi o faʻamaʻi pipisi.
Pei ona tatou iloa uma, vitamini C e mafai ona puipuia le siama ma faʻaleleia le tali atu i le puipuiga. Ae maise lava faʻasino i le taua tulaga o le COVID-19, vitamini C faia se vaega taua. O lalo-faʻatonutonuina le afa cytokine, puipuia le endothelium mai oxidative faʻaleagaina, faia se taua vaega i le toe faʻaleleia tino, ma faʻaleleia le puipuia tali atu i siama.
Ua fautuaina e le tusitala le tatau ona faʻaopopoina o vailaʻau ole vailaʻau C i aso uma e faʻamalosiʻau ai i vaega e tele le aʻafiaga ile maualuga ole maliu ole COVID-19 ma le le atoatoa ole vitamini C. Latou tatau ona faʻamautinoa i taimi uma o le vitamini C ua lava ma faʻateleina le fualaʻau pe a siama le siama, e oʻo atu i le 6-8 g / aso. O loʻo faʻaauau pea i le lalolagi atoa le aofaʻi o vailaʻau-faʻalagolago ile vailaʻau C cohort, e faʻamautuina ai lana matafaioi i le faʻamamaina o le COVID-19 ma ia malamalama lelei ai i lana matafaioi o se vailaʻau aoga.
Faʻasalalauga o le a lolomiina muamua faʻasaienisi lipoti e leʻi iloiloina e uo, ma o lea e le tatau ai ona manatu faʻamaonia, taʻitaʻia le faʻataʻitaʻi / faʻafitauli e fesoʻotaʻi ile soifua maloloina poʻo le mautinoa o faʻamatalaga mautinoa.
Tags: matuitui respiratory respiratory syndrome, anti-inflammatory, antioxidant, ascorbic acid, toto, broccoli, chemokine, coronavirus, faamai o le coronavirus COVID-19, corticosteroid, cortisol, cytokine, cytokine, manava manava, alualu i luma, Glucocorticoids, homone, tali atu tetee, tetee faiga, fulafula, interstitial, fatugaʻo, fatugaʻo faamaʻi, fatugao toilalo, olaga faitino, soifua maloloina, oxidative popolevale, pandemia, niumonia, respiratory, SARS-CoV-2, scurvy, Sepsis, ogaoga manava manava manava, ogaoga respiratory respiratory, strawberry, stress , syndrome, fualaʻau, siama, vitamini C
Ramya ei ai lona PhD. O le Pune National Chemical Laboratory (CSIR-NCL) na mauaina le PhD i le Biotechnology. O lana galuega e aofia ai le faʻatinoina o nanoparticles ma molelaʻele eseese o meaola e fiafia i ai, suʻesuʻe tali atu i faʻagaioiga ma le fausiaina o aoga aoga.
Dwivedi, Ramya. (2020, Oketopa 23). Vitamini C ma COVID-19: O se toe iloiloga. Tala Fou faafomai. Toe aumai mai https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx ia Novema 12, 2020.
Dwivedi, Ramya. "Vitamin C and COVID-19: A Review." News medical. November 12, 2020. .
Dwivedi, Ramya. "Vitamin C and COVID-19: A Review." News medical. https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx. (Accessed on November 12, 2020).
Dwivedi, Ramya. 2020. "Vitamin C and COVID-19: A Review." News-Medical, browsed on November 12, 2020, https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx.
I le faʻatalatalanoaga lenei, na faʻasalalau ai e le polofesa Paul Tesar ma Kevin Allan talafou i tusi talaʻaga faʻafomaʻi e uiga i le maualalo o le okesene e faʻaleagaina ai le faiʻai.
I lenei faatalatalanoaga, na talanoaina ai e Dr.Jiang Yigang le ACROBiosystems ma ana taumafaiga i le teteeina o le COVID-19 ma le sailia o tui puipuia
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