Vitamin C, makwaara dị ka ascorbic acid, bụ ihe dị oké mkpa mmiri-soluble potassium. Hummụ mmadụ na ụfọdụ anụmanụ ndị ọzọ (dị ka primates, ezì) dabere na vitamin C na nri na-edozi ahụ nke mkpụrụ osisi na akwụkwọ nri (ose na-acha uhie uhie, oroma, strawberry, broccoli, mango, lemon). Achọpụtala ọrụ nwere vitamin C na igbochi ma melite ọrịa na mpaghara ahụike.
Ascorbic acid dị mkpa maka nzaghachi ahụ. Ọ nwere ihe dị mkpa mgbochi mkpali, immunomodulatory, antioxidant, mgbochi thrombosis na mgbochi nje Njirimara.
Vitamin C seems to be able to regulate the host's response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus is the causative factor of the 2019 coronavirus disease (COVID-19) pandemic, especially It is in a critical period. In a recent comment published in Preprints*, Patrick Holford et al. Solved the role of vitamin C as an auxiliary treatment for respiratory infections, sepsis and COVID-19.
Isiokwu a na-atụle oke ọrụ nke vitamin C na igbochi ọkwa dị oke egwu nke COVID-19, nnukwu ọrịa iku ume na ọrịa ndị ọzọ na-efe efe. A na-atụ anya na mgbakwunye vitamin C ga-abụ mgbochi ma ọ bụ ọgwụgwọ maka mmezigharị mmejọ nke COVID-19 nke ọrịa ahụ na-akpata, na-ebelata nrụgide oxidative, na-eme ka mmepụta interferon na-akwado ma na-akwado mmetụta mgbochi mkpali nke glucocorticoids.
Iji nọgide na-enwe ọkwa plasma kwesịrị ekwesị na ndị okenye na 50 µmol / l, vitamin C usoro ọgwụgwọ maka ụmụ nwoke bụ 90 mg / d na ụmụ nwanyị 80 mg / d. Nke a ezuola igbochi scurvy (ọrịa nke enweghị vitamin C) kpatara. Agbanyeghị, ọkwa a ezughi iji gbochie ịrịa nje na nrụgide ahụike.
Therefore, the Swiss Nutrition Society recommends supplementing each person with 200 mg of vitamin C-to fill the nutritional gap of the general population, especially adults 65 years and older. This supplement is designed to strengthen the immune system. "
N’okpuru ọnọdụ nrụgide ahụike, ogo mmiri vitamin C na-agbadata ngwa ngwa. Ọrịa vitamin C nke ndị ọrịa nọ n'ụlọ ọgwụ bụ ≤11µmol / l, ọtụtụ n'ime ha na-arịa ajọ ọrịa iku ume, sepsis ma ọ bụ nnukwu COVID-19.
Ihe ọmụmụ dị iche iche sitere na gburugburu ụwa na-egosi na obere vitamin C na-adịkarị n'ọrịa ndị ọrịa na-arịa ọrịa na-arịa ọrịa iku ume, oyi baa, sepsis na COVID-19-nkọwa yikarịrị ka ọ bụ ụba nri metabolism.
Meta-analysis mere ka a mara ihe ndị a: 1) Vitamin C supplementation nwere ike belata ihe ize ndụ nke oyi baa, 2) Nnyocha a na-eme mgbe a nwụsịrị site na COVID-19 gosipụtara ọnya nke abụọ, yana 3) Vitamin C enweghị ọnụ ọgụgụ ndị mmadụ niile nwere ka oyi baa 62%.
Vitamin C nwere mmetụta dị mkpa homeostatic dị ka antioxidant. A maara ya na ọ nwere ọrụ igbu nje ozugbo na ọ nwere ike ịbawanye mmepụta nke interferon. Ọ nwere usoro nrụpụta ihe na sistemu ebumpụta ụwa na nke na-agbanwe agbanwe. Vitamin C na-ebelata ụdị ikuku oxygen (ROS) na mbufụt site na mbenata ọrụ NF-κB.
SARS-CoV-2 down-regulates the expression of type 1 interferon (the host's main antiviral defense mechanism), while ascorbic acid up-regulates these key host defense proteins.
Akụkụ dị oke egwu nke COVID-19 (nke na-abụkarị ọnọdụ na-egbu egbu) na-eme n'oge nrụpụta dị oke nke cytokines pro-inflammatory na chemokines. Nke a dugara n’ibute ọtụtụ akụkụ arụ ọrụ. O metụtara mbugharị na mkpokọta nke neutrophils na ngụgụ interstitium na oghere bronchoalveolar, nke ikpeazụ bụ isi ihe na-ekpebi nsogbu ARDS (Nnukwu Nsogbu Ọrịa Na-ahụ Maka Ọrịa).
Nchịkọta nke ascorbic acid dị na adrenal gland na pituitary gland dị okpukpu atọ ma ọ bụ okpukpu iri karịa ihe ọ bụla ọzọ. N'okpuru nrụgide physiology (mkpali ACTH) ọnọdụ gụnyere ikpughe ọrịa, a na-ewepụta vitamin C site na cortex adrenal, na-eme ka ọkwa plasma mụbaa okpukpu ise.
Vitamin C nwere ike ime ka mmepụta nke cortisol dịkwuo elu, ma mee ka mgbochi mgbochi na endothelial cell mmetụta nchedo nke glucocorticoids. Ezigbo ọgwụ glucocorticoid bụ naanị ọgwụ ndị egosila na ha na-emeso COVID-19. Vitamin C bụ ihe na-akpali akpali nke na-akpali akpali, nke na-arụ ọrụ dị mkpa n'ime mgbasa ozi nke nrụgide nrụgide adrenal cortex (karịsịa sepsis) na ichebe endothelium site na mmebi oxidative.
Accounttụle mmetụta nke vitamin C na oyi na-ebelata oge, ogo na ugboro ole ị na-a vitaminụ vitamin C nwere ike belata ntugharị site na ọrịa dị nro ruo oge dị oke egwu nke COVID-19.
Achọpụtala na vitamin C supplementation nwere ike belata oge ịnọ na ICU, belata oge ikuku nke ndị ọrịa na-arịa ọrịa COVID-19, ma belata ọnụ ọgụgụ ọnwụ nke ndị ọrịa sepsis chọrọ ọgwụgwọ na vasopressors.
N'iburu n'uche ọnọdụ dị iche iche nke afọ ọsịsa, akụrụ akụrụ na ọdịda akụrụngwa n'oge mgbatị dị elu, ndị ode akwụkwọ tụlere nchekwa nke nchịkwa nke ọgwụ na ọgwụ nje nke vitamin C. Enwere ike ịkwado nnukwu ọgwụ dị mkpụmkpụ nke 2-8 g / ụbọchị ( jiri nlezianya zere akwa doses maka ndị nwere akụkọ banyere akụrụ akụrụ ma ọ bụ ọrịa akụrụ). Ebe ọ bụ na ọ bụ mmiri nwere ike ịgbanye, ọ nwere ike wepụ ya n'ime awa ole na ole, ya mere usoro onunu ogwu dị mkpa iji jigide ogo ọbara zuru oke n'oge ọrịa na-arụ ọrụ.
Dị ka anyị niile maara, vitamin C nwere ike igbochi ọrịa ma melite nzaghachi mgbochi. Karịsịa na-ezo aka n'oge dị egwu nke COVID-19, vitamin C na-arụ ọrụ dị mkpa. Ọ na-achịkwa oké ifufe cytokine, na-echebe endothelium site na mmebi nke oxidative, na-arụ ọrụ dị mkpa na ndozi anụ ahụ, ma na-eme ka mmeghachi ahụ na-adịghị mma na ọrịa.
Onye edemede ahụ na-atụ aro na a ga-agbakwunye vitamin C kwa ụbọchị iji gbaa ìgwè dị egwu egwu na nnukwu ọnwụ COVID-19 na ụkọ vitamin C. Ha kwesiri ijide n'aka na vitamin C zuru oke ma bawanye ọgwụ mgbe nje a bu nje, ruo 6-8 g / ụbọchị. Ọtụtụ ihe ọmụmụ vitamin C na-adabere na dose na-aga n'ihu n'ụwa niile iji kwado ọrụ ya na ibelata COVID-19 na ịmatakwu ọrụ ya dị ka ikike ọgwụgwọ.
Ndị na-ebu ụzọ ga-ebipụta akụkọ sayensị nke mbido nke a na-enyochabeghị, ọ bụ ya mere na ekwesighi ka elere anya na ya, na-eduzi omume ahụike / omume metụtara ahụike ma ọ bụ were ozi doro anya.
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Ramya nwere PhD. Pune National Chemical Laboratory (CSIR-NCL) nwetara PhD na Biotechnology. Ọrụ ya na-agụnye ịrụ ọrụ nanoparticles dị iche iche ụmụ irighiri ihe ndị dị ndụ, na-amụ usoro mmeghachi omume na iwuli ngwa bara uru.
Dwivedi, Ramya. (2020, Ọktọba 23). Vitamin C na COVID-19: Nyocha. Akụkọ ahụike. Weghachiri na https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx na November 12, 2020.
Dwivedi, Ramya. "Vitamin C and COVID-19: A Review." News medical. November 12, 2020. .
Dwivedi, Ramya. "Vitamin C and COVID-19: A Review." News medical. https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx. (Accessed on November 12, 2020).
Dwivedi, Ramya. 2020. "Vitamin C and COVID-19: A Review." News-Medical, browsed on November 12, 2020, https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx.
N'ajụjụ ọnụ a, Prọfesọ Paul Tesar na Kevin Allan bipụtara akụkọ na akwụkwọ akụkọ ahụike banyere oke ikuku oxygen na-emebi ụbụrụ.
N'ajụjụ ọnụ a, Dr. Jiang Yigang kwurịtara banyere ACROBiosystems na mbọ ọ na-agba n'ịlụ ọgụ COVID-19 na ịchọta ọgwụ mgbochi
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