ʻO ka Wikamina C, i ʻike ʻia ʻo ascorbic acid, kahi mea pono o ka wai e hoʻoheheʻe ʻia i ka wai. ʻO nā kānaka a me kekahi mau holoholona ʻē aʻe (e like me nā primata, nā puaʻa) kaukaʻi ʻia i ka wikamina C i ka lako pono o nā huaʻai a me nā mea kanu (pepa ʻulaʻula, ʻalani, strawberry, broccoli, manga, lemon). ʻO ke kūlana kūpono o ka wikamina C i ka pale ʻana a me ka hoʻomaikaʻi ʻana i nā maʻi i ʻike ʻia i ke kaiāulu.
Pono ka Ascorbic acid i ka pane pale. Loaʻa iā ia he anti-inflammatory nui, immunomodulatory, antioxidant, anti-thrombosis a me anti-viral waiwai.
Vitamin C seems to be able to regulate the host's response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus is the causative factor of the 2019 coronavirus disease (COVID-19) pandemic, especially It is in a critical period. In a recent comment published in Preprints*, Patrick Holford et al. Solved the role of vitamin C as an auxiliary treatment for respiratory infections, sepsis and COVID-19.
Kūkākūkā kēia ʻatikala i ka hana kūpono o ka wikamina C i ka pale ʻana i ke kahua koʻikoʻi o COVID-19, nā maʻi hanu ʻeha a me nā maʻi ʻino ʻē aʻe. ʻO Vitamin C supplementation ka mea i pale ʻia a i lāʻau lapaʻau paha no COVID-19-e hoʻoponopono ana i nā hemahema i hoʻokumu ʻia e ka maʻi, e hoʻoliʻiliʻi ana i ke koʻikoʻi oxidative, e hoʻonui ana i ka hana interferon a me ke kākoʻo ʻana i nā hopena anti-inflammatory o nā glucocorticoids.
I mea e mālama ai i nā pae plasma maʻamau i nā mākua ma 50 µmol / l, ʻo ka mahele lāʻau C no nā kāne he 90 mg / d a no nā wahine 80 mg / d. Ua lawa kēia e pale aku ai i ka scurvy (kahi maʻi i hoʻokumu ʻia e ka nele o ka wikamina C). Eia naʻe, ʻaʻole lawa kēia pae e pale ai i ka hōʻike viral a me ke koʻikoʻi koʻikoʻi.
Therefore, the Swiss Nutrition Society recommends supplementing each person with 200 mg of vitamin C-to fill the nutritional gap of the general population, especially adults 65 years and older. This supplement is designed to strengthen the immune system. "
Ma lalo o nā kūlana koʻikoʻi physiological, hāʻule wikiwiki nā pae lāʻau serum kanaka C. ʻO ka maʻi vitamin C serum o nā mea maʻi i hōʻola ʻia ʻo ≤11µmol / l, a ʻo ka hapa nui o lākou e ʻeha nei i ka maʻi hanu koʻikoʻi, sepsis a i ʻole COVID-19 koʻikoʻi.
Hōʻike nā ʻano hihia like ʻole mai ka honua holoʻokoʻa i ka pae haʻahaʻa o ka vitamona C i nā maʻi maʻi loa me nā maʻi hanu, ka maʻi ponia, sepsis a me COVID-19-ʻo ka wehewehe kūpono ka hoʻonui ʻia o ka ʻai i ka metabolic.
Ua hōʻike ʻia ka meta-analysis i kēia mau mea i ʻike ʻia: 1) Hiki i ka supplementation Vitamin C ke hoʻemi nui i ka makaʻu o ka maʻi puluma, 2) Ma hope o ka make ʻana mai COVID-19, ua hōʻike ʻia ka pneumonia lua, a me 3) ʻo ka hemahema ʻo Vitamin C ka helu no ka heluna lehulehu me pulumea 62%.
He hopena homeostatic koʻikoʻi ka Vitamin C ma ke ʻano he antioxidant. ʻIke ʻia he hana hoʻomake virus pololei a hiki ke hoʻonui i ka hana o interferon. Loaʻa iā ia nā ʻano hana i loko o nā ʻōnaehana pale ʻelua a me nā adaptive. Hoʻoiho ka Vitamin C i nā oxygen oxygen reactive (ROS) a me ka mumū ma ka hōʻemi ʻana i ka hoʻoulu ʻana o NF-κB.
SARS-CoV-2 down-regulates the expression of type 1 interferon (the host's main antiviral defense mechanism), while ascorbic acid up-regulates these key host defense proteins.
ʻO ka pae koʻikoʻi o COVID-19 (ʻo ka maʻa mau ka hopena make) kū i ka wā o ka hana nui ʻana o nā cytokine pro-inflammatory pono a me nā chemokines. Ua alakaʻi kēia i ka hoʻomohala ʻana i nā hanana maha ʻole. Pili ia i ka neʻe ʻana a me ka hōʻiliʻili ʻana o nā neutrophil i loko o ka lung interstitium a me ka lua o ka bronchoalveolar, a ʻo ka mea hope loa ke kī nui o ka ARDS (Acute Respiratory Distress Syndrome).
ʻO ke kukuna o ka ascorbic acid i loko o nā adrenal glands a me ka pituitary gland ʻekolu a he ʻumi mau manawa ke kiʻekiʻe ma mua o nā meaola ʻē aʻe. Ma lalo o ke koʻikoʻi koʻikoʻi (ACTH stimulate) nā kūlana e like me ka hōʻike viral, hoʻokuʻu ʻia ka wikamina C mai ka adrenal cortex, e hoʻonui ana i nā pae plasma ʻelima mau pā.
Hiki i ka Vitamin C ke hoʻonui i ka hana o ka cortisol, a hoʻonui i ka hopena pale anti-inflammatory a me endothelial cell o nā glucocorticoids. ʻO nā Exogenous glucocorticoid steroid wale nō nā lāʻau i hōʻoia ʻia e mālama iā COVID-19. ʻO ka Vitamin C kahi hormone hoʻonāukiuki nui-hopena, kahi mea nui i ka mediasi i ka pane adrenal cortex stress (ʻo ia hoʻi ka sepsis) a me ka pale ʻana i ka endothelium mai ka hōʻino oxidative.
I ka noʻonoʻo ʻana i ka hopena o ka wikamina C ma ke anuanu-e hoʻēmi ana i ka lōʻihi, ke koʻikoʻi a me ke alapine o ke anuanu e lawe ana i ka wikamina C hiki ke hōʻemi i ka hoʻololi mai ka maʻi ahulau i ka wā koʻikoʻi o COVID-19.
Ua ʻike ʻia hiki ke hoʻopōkole ʻia ka hoʻolauna vitam C i ka lōʻihi o ka noho ʻana i ka ICU, hoʻopōkole i ka manawa hoʻokomo o nā mea maʻi maʻi me COVID-19, a hoʻemi i ka helu make o nā mea maʻi sepsis e koi ʻia me ka vasopressors.
I ka noʻonoʻo ʻana i nā ʻano like ʻole o ka maʻi pākī, nā pōhaku hakuʻala a me nā kō ʻole o ke kōkō i nā wā kiʻekiʻe, ua kūkākūkā nā mea kākau i ka palekana o ka lawelawe waha a me ka intravenous o ka huaora C. Hiki ke ʻōlelo ʻia kahi mahele lāʻau lōʻihi pōkole o 2-8 g / lā ( e hōʻalo pono i nā kiʻekiʻena kiʻekiʻe no ka poʻe me ka mōʻaukala o nā pōhaku kōkō a i ʻole nā ​​maʻi puʻukū. Ma muli o ka maʻalahi o ka wai, hiki ke excreted i loko o kekahi mau hola, no laila he mea nui ka pinepine pinepine e mālama i nā kiʻekiʻe o ke koko i ka wā o ka maʻi maʻamau.
E like me kā mākou āpau, hiki i ka wikamina C ke pale aku i ka maʻi a hoʻomaikaʻi i ka pane pale. Ke kuhikuhi nei hoʻi i ka pae koʻikoʻi o COVID-19, he kī nui ka wikamina C. Mālama ʻo ia i lalo i ka cytokine storm, pale i ka endothelium mai ka hōʻino ʻana o ka oxidative, he kuleana nui i ka hoʻoponopono ʻana i nā ʻaʻa, a hoʻomaikaʻi i ka pane pale ʻana i ka maʻi.
Paipai ka mea kākau i ka hoʻohui ʻia ʻana o ka wikamina C i kēlā me kēia lā e paipai i nā hui kiʻekiʻe me ka make ʻana COVID-19 kiʻekiʻe a me ka hemahema o ka wikamina C. E hōʻoia mau lākou i ka lawa pono o ka wikamina C a hoʻonui i ka lāʻau i ka wā e maʻi ai ka maʻi, a 6-8 g / lā. Ke hoʻomau nei nā helu o nā lāʻau c-c wikamina C cohort i ka honua holoʻokoʻa e hōʻoia i kāna kuleana i ka hoʻomaha ʻana iā COVID-19 a e hoʻomaopopo maikaʻi i kāna kuleana ma ke ʻano he therapeutic potensial.
E paʻi nā Preprints i nā hōʻike ʻepekema mua i nānā ʻole ʻia e nā hoa, a no laila ʻaʻole pono e noʻonoʻo ʻia he alakaʻi, alakaʻi ʻana i nā hana olakino / nā hana pili i ke olakino a i ʻole ʻike ʻia ka ʻike paʻa.
Tags: maʻi kūpilikiʻi respiratory respiratory syndrome, anti-inflammatory, antioxidant, ascorbic acid, koko, broccoli, chemokine, coronavirus, maʻi coronavirus COVID-19, corticosteroid, cortisol, cytokine, cytokine, diarrhea, frequency, Glucocorticoids, hormones, immune pane, immune ʻōnaehana, pākī, interstitial, hakuʻala, maʻi hakuʻala, hakuʻala pono ʻole, make, ʻai pono, oxidative stress, pandemikō, pneumonia, respiratory, SARS-CoV-2, scurvy, Sepsis, maʻi kūpikipikiʻi respiratory respiratory, koʻikoʻi koʻikoʻi respiratory respiratory, strawberry, stress , maʻi, nā mea kanu, nā mea hoʻomaʻi, ka wikamina C
Ramya loaʻa kahi PhD. Ua loaʻa i ka Pune National Chemical Laboratory (CSIR-NCL) kahi PhD ma Biotechnology. ʻO kāna hana e komo pū ana me nā nanoparticle hana me nā ʻulaʻula ʻokoʻa o ka pono olaola, ke aʻo ʻana i nā ʻōnaehana hopena a me ke kūkulu ʻana i nā noi pono.
ʻO Dwivedi, Ramya. (2020, ʻOkakopa 23). ʻO Vitamin C a me COVID-19: He loiloi. Lapaʻau nūhou. Ua kiʻi ʻia mai https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx ma Nowemapa 12, 2020.
Dwivedi, Ramya. "Vitamin C and COVID-19: A Review." News medical. November 12, 2020. .
Dwivedi, Ramya. "Vitamin C and COVID-19: A Review." News medical. https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx. (Accessed on November 12, 2020).
Dwivedi, Ramya. 2020. "Vitamin C and COVID-19: A Review." News-Medical, browsed on November 12, 2020, https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx.
I kēia nīnauele, ua hoʻolaha ʻo Polofesa Paul Tesar lāua ʻo Kevin Allan i ka nūhou i nā puke pai nūhou e pili ana i ka haʻahaʻa o ka oxygen i hōʻino i ka lolo.
Ma kēia nīnauele, ua kūkākūkā ʻo Kauka Jiang Yigang i ka ACROBiosystems a me kāna mau hana i ke kaua ʻana iā COVID-19 a me ka loaʻa ʻana o nā lāʻau āpau
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Hāʻawi ʻo News-Medical.Net i kēia lawelawe ʻike ʻike olakino e like me kēia mau ʻōlelo. E ʻoluʻolu e hoʻohana wale ʻia ka ʻike olakino i loaʻa ma kēia pūnaewele e kākoʻo a ʻaʻole hoʻi e pani i ka pilina ma waena o nā mea maʻi a me nā kauka a me nā ʻōlelo aʻoaʻo a lākou e hāʻawi ai.
Hoʻohana mākou i nā kuki e hoʻomaikaʻi i kou ʻike. Ma ka hoʻomau ʻana e nānā i kēia pūnaewele, ʻae ʻoe i kā mākou hoʻohana ʻana i nā kuki. ʻIke hou aku.