Vitamin C, tseem hu ua ascorbic acid, yog qhov muaj dej-soluble zoo rau lub cev. Tib neeg thiab lwm yam tsiaj (xws li tsiaj liab, npua) yog nyob ntawm cov vitamin C hauv zaub mov txiv hmab txiv ntoo thiab zaub (kua txob liab, txiv kab ntxwv, txiv pos nphuab, zaub cob pob, txiv nkhaus taw, txiv qaub). Lub luag haujlwm tseem ceeb ntawm cov vitamin C hauv kev tiv thaiv thiab txhim kho kev sib kis tau pom zoo hauv zej zog kev kho mob.
Ascorbic acid yog qhov tseem ceeb rau kev tiv thaiv kab mob. Nws muaj cov khoom tseem ceeb los tiv thaiv kev tiv thaiv, tiv thaiv kab mob, tshuaj tua kab mob tiv thaiv, tiv thaiv cov leeg mob thiab tawm tsam.
Vitamin C seems to be able to regulate the host's response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus is the causative factor of the 2019 coronavirus disease (COVID-19) pandemic, especially It is in a critical period. In a recent comment published in Preprints*, Patrick Holford et al. Solved the role of vitamin C as an auxiliary treatment for respiratory infections, sepsis and COVID-19.
Tsab xov xwm no tham txog qhov muaj peev xwm ntau ntawm cov vitamin C hauv kev tiv thaiv theem tseem ceeb ntawm COVID-19, mob ntsws ua pa nyuaj thiab lwm yam kab mob. Vitamin C ntxiv tau cia siab tias yog kev tiv thaiv lossis kho tus neeg sawv cev rau COVID-19-kho qhov ua kom tsis zoo los ntawm tus kab mob, txo qis oxidative kev nyuaj siab, txhim kho interferon ntau lawm thiab txhawb cov tshuaj tiv thaiv los ntawm glucocorticoids.
Txhawm rau tswj cov ntshav plasma ib txwm muaj hauv cov neeg laus ntawm 50 µmol / l, kev noj tshuaj vitamin C rau txiv neej yog 90 mg / d thiab rau cov poj niam 80 mg / d. Qhov no yog txaus kom tiv thaiv scurvy (kab mob tshwm sim los ntawm qhov tsis muaj vitamin C). Txawm li cas los xij, theem no tsis txaus los tiv thaiv kev kis kab mob thiab kev ntxhov siab ntawm lub cev.
Therefore, the Swiss Nutrition Society recommends supplementing each person with 200 mg of vitamin C-to fill the nutritional gap of the general population, especially adults 65 years and older. This supplement is designed to strengthen the immune system. "
Hauv qab kev mob kev nyuaj siab mob hlwb, tib neeg cov ntshav vitamin C poob qis. Cov dej ntshiab vitamin C cov ntsiab lus ntawm cov neeg mob pw hauv tsev kho mob yog ≤11µmol / l, thiab feem ntau ntawm lawv muaj mob voos mob hnyav, sepsis lossis mob hnyav QHI-19.
Cov kev tshawb fawb pom ntau yam los ntawm thoob plaws lub ntiaj teb qhia tias muaj cov vitamin C tsawg nyob rau hauv cov neeg mob loj hauv tsev kho mob uas muaj kab mob ua pa, mob ntsws, mob sepsis thiab COVID-19-qhov kev piav qhia feem ntau yog kev noj zaub mov ntau ntxiv.
Kev tshawb xyuas meta tau hais txog kev soj ntsuam hauv qab no: 1) Kev noj tshuaj ntxiv rau Vitamin C tuaj yeem txo qhov kev pheej hmoo mob ntsws, 2) kev tshawb nrhiav tom qab tuag tag tom qab kev tuag los ntawm COVID-19 qhia txog kev mob ntsws muaj thib ob, thiab 3) Vitamin C tsis txaus ntseeg txog tag nrho cov pejxeem nrog mob ntsws 62%.
Vitamin C muaj cov nyhuv tseem ceeb hauv tsev ua haujlwm tiv thaiv kab mob. Nws raug paub muaj cov kab mob tua cov kabmob kev ua haujlwm ncaj qha thiab tuaj yeem nce ntau ntxiv ntawm interferon. Nws muaj effector cov tswv yim hauv ob qho tib si innate thiab hloov lub cev tsis muaj zog. Vitamin C txo cov tshuaj oxygen reactive (ROS) thiab mob los ntawm kev txo qis kom ua haujlwm ntawm NF-κB.
SARS-CoV-2 down-regulates the expression of type 1 interferon (the host's main antiviral defense mechanism), while ascorbic acid up-regulates these key host defense proteins.
Cov theem tseem ceeb ntawm COVID-19 (feem ntau ua rau cov neeg tuag taus) tshwm sim thaum lub sijhawm ua haujlwm dhau ntawm kev ua kom muaj txiaj ntsig pro-inflammatory cytokines thiab chemokines. Qhov no coj mus rau kev txhim kho ntawm ntau yam khoom hauv lub cev tsis ua haujlwm. Nws muaj feem xyuam rau kev tsiv teb tsaws thiab kev tsub zuj zus ntawm neutrophils nyob rau hauv lub ntsws interstitium thiab bronchoalveolar kab noj hniav, tom kawg ua tus txiav txim tseem ceeb ntawm ARDS (Mob Kev Mob Hlav Mob Hlav).
Qhov kev xav ntawm ascorbic acid nyob rau hauv cov qog adrenal thiab cov qog pituitary yog peb mus rau kaum lub sij hawm ntau dua li lwm qhov hauv lub cev. Nyob rau ntawm lub cev kev nyuaj siab (ACTH stimulation) cov xwm txheej nrog rau kis kab mob, vitamin C tso tawm los ntawm adrenal cortex, ua rau muaj ntshav nce ntxiv mus rau tsib zaug.
Vitamin C tuaj yeem txhim kho kev tsim tawm ntawm cortisol, thiab txhim kho lub anti-inflammatory thiab endothelial cell tiv thaiv ntawm glucocorticoids. Exogenous glucocorticoid steroids yog cov tshuaj nkaus xwb uas tau raug pov thawj los kho COVID-19. Vitamin C yog ntau cov nyhuv stimulating hormone, uas ua lub luag haujlwm tseem ceeb hauv kev kho kom zoo rau adrenal cortex cov lus teb kev nyuaj siab (tshwj xeeb tshaj yog sepsis) thiab tiv thaiv cov endothelium los ntawm kev puas tsuaj oxidative.
Kev txiav txim siab qhov tshwm sim ntawm cov vitamin C rau qhov txias-txo lub sijhawm, mob hnyav thiab ntau zaus ntawm kev noj khaub thuas noj tshuaj vitamin C tuaj yeem txo qhov kev hloov pauv ntawm kev kis mob me mus rau lub sijhawm tseem ceeb ntawm COVID-19.
Nws tau raug pom tias kev noj tshuaj vitamin C tuaj yeem ua rau lub sijhawm ntev nyob hauv ICU, ua kom lub sijhawm ua pa tawm ntawm cov neeg mob tsis txaus siab rau COVID-19, thiab txo qis kev tuag ntawm cov neeg mob sepsis uas xav tau kev kho mob nrog vasopressors.
Ua tib zoo xav txog ntau yam mob ntawm zawv plab, lub raum lub raum thiab lub raum tsis ua haujlwm thaum siv tshuaj ntau, cov kws sau ntawv tau sib tham txog kev nyab xeeb ntawm qhov ncauj thiab txoj kev saib xyuas ntawm cov tshuaj vitamin C. ua tib zoo zam tsis txhob txhaj cov koob tshuaj ntau rau cov neeg uas muaj keeb kwm mob raum pob zeb los yog mob raum. Vim tias nws yog dej-soluble, nws tuaj yeem tawm hauv ob peb teev, yog li ntau npaum li cas yog qhov tseem ceeb los tswj kom muaj ntshav txaus thaum mus sib kis.
Raws li peb txhua tus paub, vitamin C tuaj yeem tiv thaiv kev kis kab mob thiab txhim kho kev tiv thaiv kab mob. Tshwj xeeb tshaj yog hais txog theem tseem ceeb ntawm COVID-19, vitamin C ua lub luag haujlwm tseem ceeb. Nws poob-tswj hwm cytokine cua daj cua dub, tiv thaiv endothelium los ntawm kev puas tsuaj oxidative, lub luag haujlwm tseem ceeb hauv kev kho cov ntaub so ntswg, thiab txhim kho lub cev tsis muaj zog tiv thaiv kev kis mob.
Tus kws sau ntawv pom zoo tias yuav tsum tau ntxiv cov tshuaj vitamin C ntxiv rau txhua hnub los txhawb cov neeg muaj kev phom sij uas muaj COVID-19 cov neeg tuag thiab cov vitamin C tsis txaus. Lawv yuav tsum nco ntsoov tias muaj cov vitamin C txaus thiab nce cov koob tshuaj thaum tus kabmob kis tau, nce mus txog 6-8 g / hnub. Tus nab npawb ntawm cov koob tshuaj vitamin C cohort cov kev tshawb fawb tseem tab tom thoob ntiaj teb kom paub meej tias nws lub luag haujlwm hauv kev tiv thaiv COVID-19 thiab kom nkag siab zoo txog nws lub luag haujlwm yog qhov muaj peev xwm kho tau.
Cov ntawv tshaj tawm yuav tshaj tawm cov ntawv tshaj tawm tshawb fawb ua ntej uas tsis tau raug tshuaj xyuas, thiab yog li ntawd yuav tsum tsis txhob suav tias yog muaj txiaj ntsig, kev coj ua hauv chaw kho mob / kev coj tus cwj pwm kev noj qab haus huv lossis txiav txim siab cov ntaub ntawv tseem ceeb.
Cov cim npe: mob ntsws ua pa nyuaj, tiv thaiv mob, tshuaj tiv thaiv kab mob, ascorbic acid, ntshav, zaub cob pob, tshuaj tua kab mob, mob coronavirus, mob coronavirus COVID-19, corticosteroid, cortisol, cytokine, cytokine, raws plab, ntau zaus, Glucocorticoids, cov tshuaj hormones, tiv thaiv kab mob, tiv thaiv kab mob cov kab ke, mob o, mob raum, mob raum, mob raum, lub raum tsis ua haujlwm, tuag, khoom noj khoom haus, oxidative kev nyuaj siab, pandemic, mob ntsws, ua pa, SARS-CoV-2, scurvy, Sepsis, mob ntsws ua pa nyuaj, mob ua pa nyuaj ua pa nyuaj, pos nphuab, kev nyuaj siab , mob ntsws, zaub, kab mob, vitamin C
Ramya muaj PhD. Pune National Chemical Laboratory (CSIR-NCL) tau txais PhD hauv Biotechnology. Nws ua haujlwm suav nrog kev ua haujlwm ntawm nanoparticles nrog cov sib txawv lwg ntawm kev txaus siab lom neeg, kawm txog cov tshuaj tiv thaiv kev ua haujlwm thiab kev tsim cov ntawv thov muaj txiaj ntsig.
Dwivedi, Ramya. (2020, Kaum Hli 23). Vitamin C thiab COVID-19: Tshuaj xyuas. Xov xwm kho mob. Muab los ntawm https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx lub Kaum Ib Hlis 12, 2020.
Dwivedi, Ramya. "Vitamin C and COVID-19: A Review." News medical. November 12, 2020. .
Dwivedi, Ramya. "Vitamin C and COVID-19: A Review." News medical. https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx. (Accessed on November 12, 2020).
Dwivedi, Ramya. 2020. "Vitamin C and COVID-19: A Review." News-Medical, browsed on November 12, 2020, https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx.
Hauv kev xam phaj no, xibfwb Paul Tesar thiab Kevin Allan tau tshaj tawm cov xov xwm rau kev tshaj xov xwm kho mob txog kev qis oxygen tsawg npaum li cas rau lub hlwb.
Hauv kev xam phaj no, Dr. Jiang Yigang tau tham txog ACROBiosystems thiab nws cov kev siv zog tiv thaiv COVID-19 thiab nrhiav tshuaj tiv thaiv nyob
rau hauv kev sib tham no, Xov Xwm-Medical tau sib tham txog kev txhim kho thiab kev paub txog cov tshuaj tiv thaiv monoclonal nrog David Apiyo, tus thawj saib xyuas hauv kev thov ntawm Sartorius AG.
Xov Xwm-Medical.Net muab cov ntaub ntawv kho mob no raws li cov lus thiab cov mob no. Thov nco ntsoov tias cov ntaub ntawv kho mob muaj nyob hauv lub vev xaib no tsuas yog siv los txhawb nqa thiab tsis hloov txoj kev sib raug zoo ntawm cov neeg mob thiab cov kws kho mob thiab cov lus qhia kho mob uas lawv yuav muab.
Peb siv cov ncuav qab zib los txhim kho koj kev paub. Los ntawm txuas ntxiv mus xauj lub vev xaib no, koj pom zoo rau peb kev siv cov ncuav qab zib. Cov lus qhia ntxiv.