Vithamine C, eo hape e tsejoang e le ascorbic acid, ke phepo ea bohlokoa e qhibilihang metsing. Batho le liphoofolo tse ling (joalo ka litšoene, likolobe) ba ipapisitse le vithamine C phepong ea litholoana le meroho (pepere e khubelu, lamunu, fragola, broccoli, mango, sirilamunu). Karolo e ka bang teng ea vithamine ea C ho thibela le ho ntlafatsa tšoaetso e amohetsoe sechabeng sa bongaka.
Ascorbic acid e bohlokoa molemong oa boits'ireletso ba mmele. E na le lintho tsa bohlokoa tse khahlanong le ho ruruha, ho itšireletsa mafung, antioxidant, anti-thrombosis le anti-virus.
Vitamin C seems to be able to regulate the host's response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus is the causative factor of the 2019 coronavirus disease (COVID-19) pandemic, especially It is in a critical period. In a recent comment published in Preprints*, Patrick Holford et al. Solved the role of vitamin C as an auxiliary treatment for respiratory infections, sepsis and COVID-19.
Sengoliloeng sena se bua ka karolo e ka bang teng ea vithamine ea C ho thibela boemo ba bohlokoa ba COVID-19, mafu a tšoaetsanoang a phefumoloho le mafu a mang a hlabang. Tlatsetso ea vithamine C e lebelletsoe ho ba moemeli oa thibelo kapa oa kalafo bakeng sa bofokoli ba COVID-19 bo bakoang ke lefu lena, ho fokotsa khatello ea mali ea oksijene, ho matlafatsa tlhahiso ea li-interferon le ho ts'ehetsa litlamorao tse khahlano le ho ruruha tsa li-glucocorticoids.
Bakeng sa ho boloka maemo a tloaelehileng a plasma ho batho ba baholo ho 50 µmol / l, tekanyetso ea vithamine C bakeng sa banna ke 90 mg / d le bakeng sa basali 80 mg / d. Sena se lekane ho thibela scurvy (lefu le bakoang ke ho haella ha vithamine C). Leha ho le joalo, boemo bona ha boa lekana ho thibela tšoaetso ea vaerase le khatello ea mmele.
Therefore, the Swiss Nutrition Society recommends supplementing each person with 200 mg of vitamin C-to fill the nutritional gap of the general population, especially adults 65 years and older. This supplement is designed to strengthen the immune system. "
Tlas'a maemo a khatello ea mmele, maemo a motho a vithamine C a theoha ka potlako. Sekhahla sa vithamine C sa bakuli ba lipetlele ke ≤11µmol / l, mme boholo ba bona bo na le ts'oaetso e matla ea ho hema, sepsis kapa COVID-19 e matla.
Liphuputso tse fapaneng tse tsoang lefats'eng ka bophara li supa hore maemo a tlase a vithamine C a tloaelehile ho bakuli ba kulang haholo ba nang le ts'oaetso ea phefumoloho, pneumonia, sepsis le COVID-19-tlhaloso e ka bang teng ke ts'ebeliso ea metabolic.
Tlhatlhobo ea meta e totobalitse lintlha tse latelang: 1) Tlatsetso ea Vitamin C e ka fokotsa haholo kotsi ea pneumonia, 2) Lipatlisiso tsa lefu la kamora lefu ho tsoa ho COVID-19 li bontšitse pneumonia ea bobeli, le 3) Ho haella ha vithamine C ho bakile palo ea baahi bohle ba nang le serame sa matšoafo 62%.
Vithamine C e na le phello ea bohlokoa ea homeostatic joalo ka antioxidant. E tsejoa hore e na le ts'ebetso e tobileng ea ho bolaea vaerase mme e ka eketsa tlhahiso ea interferon. E na le mekhoa ea ho sebetsa litsing tsa 'mele tsa tlhaho le tse ikamahanyang le maemo. Vithamine C e fokotsa mefuta ea oksijene e sebetsang (ROS) le ho ruruha ka ho fokotsa ts'ebetso ea NF-κB.
SARS-CoV-2 down-regulates the expression of type 1 interferon (the host's main antiviral defense mechanism), while ascorbic acid up-regulates these key host defense proteins.
Karolo e mahlonoko ea COVID-19 (hangata karolo e bolaeang) e etsahala nakong ea tlhahiso e fetelletseng ea li-cytokine le li-chemokine tse matlafatsang. Sena se lebisitse ho nts'etsopele ea ho hloleha ha litho tse ngata. E amana le ho falla le ho bokellana ha li-neutrophils ka har'a li-interstitium tsa matšoafo le mokokotlo oa bronchoalveolar, eo e qetellang e le sesosa sa bohlokoa sa ARDS (Acute Respiratory Distress Syndrome).
Khakanyo ea asiti ea ascorbic liphatseng tsa adrenal le pituitary gland e phahame makhetlo a mararo ho isa ho a leshome ho feta setho sefe kapa sefe. Tlas'a khatello ea 'mele (ACTH stimulation) maemo a kenyeletsang tšoaetso ea vaerase, vithamine C e tsoa ho adrenal cortex, e etsang hore maemo a plasma a eketsehe hahlano.
Vithamine C e ka ntlafatsa tlhahiso ea cortisol, le ho matlafatsa lithibela-mafu le lisele tsa endothelial tse sirelletsang li-glucocorticoids. Li-steroids tsa glucocorticoid ke tsona feela lithethefatsi tse netefalitsoeng hore li phekola COVID-19. Vithamine C ke li-hormone tse matlafatsang tse nang le matla a mangata, tse phethang karolo ea bohlokoa ho feliseng karabelo ea khatello ea kelello ea adrenal (haholo-holo sepsis) le ho sireletsa endothelium tšenyo ea oxidative.
Ho nahanisisa ka phello ea vithamine C ho sefuba-ho fokotsa nako, boima le makhetlo a vithamine ea C e nkang sefuba ho ka fokotsa phetoho ho tloha tšoaetsong e bonolo ho ea nakong e mahlonoko ea COVID-19.
Ho hlokometsoe hore tlatsetso ea vithamine C e ka khutsufatsa bolelele ba nako ea ho lula ICU, ea khutsufatsa nako ea moea oa bakuli ba kulang haholo ba nang le COVID-19, le ho fokotsa sekhahla sa lefu la bakuli ba sepsis ba hlokang kalafo ka li-vasopressor.
Ha ho nahanoa ka maemo a fapaneng a letšollo, majoe a liphio le ho hloleha ha liphio nakong ea litekanyetso tse phahameng, bangoli ba buile ka polokeho ea tsamaiso ea molomo le ea methapo ea vithamine C. Ho ka buelloa tekanyetso e phahameng ea nako e khuts'oane ea 2-8 g / ka letsatsi ( qoba ka hloko litekanyetso tse phahameng bakeng sa batho ba nang le nalane ea liphio kapa lefu la liphio). Hobane e qhibiliha ka metsi, e ka tsoa kahare ho lihora tse 'maloa, kahoo maqhubu a litekanyetso a bohlokoa ho boloka maemo a lekaneng a mali nakong ea ts'oaetso e mafolofolo.
Joalokaha bohle re tseba, vithamine C e ka thibela tšoaetso le ho ntlafatsa boits'ireletso ba mmele. Haholo-holo e bua ka boemo ba bohlokoa ba COVID-19, vithamine C e bapala karolo ea bohlokoa. E theola-e laola sefefo sa cytokine, e sireletsa endothelium tšenyo ea oxidative, e bapala karolo ea bohlokoa ho lokiseng lisele, hape e ntlafatsa boits'ireletso ba mmele ho tšoaetso.
Sengoli se khothaletsa hore litlatsetso tsa vithamine C li lokela ho eketsoa letsatsi le leng le le leng ho khothaletsa lihlopha tse kotsing e kholo e nang le lefu le phahameng la COVID-19 le khaello ea vithamine C. Kamehla ba lokela ho netefatsa hore vithamine C e lekane le ho eketsa lethal dose ha vaerase e tšoaelitsoe, ho fihlela ho 6-8 g / ka letsatsi. Liphuputso tse 'maloa tsa sehlopha sa vithamine C tse itšetlehileng ka lethal dose li ntse li tsoela pele lefatšeng ka bophara ho netefatsa karolo ea eona ho feliseng COVID-19 le ho utloisisa hantle karolo ea eona e le monyetla oa kalafo.
Likhatiso tsa pele li tla phatlalatsa litlaleho tsa pele tsa mahlale tse sa kang tsa hlahlojoa ke lithaka, ka hona ha lia lokela ho nkuoa e le tsa nnete, tse tataisang litloaelo tsa bongaka / boits'oaro bo amanang le bophelo bo botle kapa ho nkuoa e le tlhaiso-leseling e hlakileng.
Litags: lefu le bohloko la ho hema, anti-inflammatory, antioxidant, ascorbic acid, mali, broccoli, chemokine, coronavirus, lefu la coronavirus COVID-19, corticosteroid, cortisol, cytokine, cytokine, letšollo, maqhubu, Glucocorticoids, lihormone, boits'ireletso ba mmele, boitshireletso ba mmele tsamaiso, ho ruruha, ho kena lipakeng, liphio, lefu la liphio, ho hloleha ha liphio, ho shoa, phepo e nepahetseng, khatello ea mali, lefu la seoa, pneumonia, ho hema, SARS-CoV-2, scurvy, Sepsis, lefu le matla la ho hema, lefu le matla la ho hema, fragola, khatello ea maikutlo , Syndrome, meroho, vaerase, vithamine C
Ramya o na le PhD. Pune National Chemical Laborator (CSIR-NCL) e fumane PhD ho Biotechnology. Mosebetsi oa hae o kenyelletsa li-nanoparticles tse sebetsang tse nang le limolek'hule tse fapaneng tse khahlisang likokoana-hloko, ho ithuta ka tšebetso ea karabelo le ho aha lits'ebetso tsa bohlokoa.
Dwivedi, Ramya. (2020, Mphalane 23). Vithamine C le COVID-19: Tlhahlobo. Litaba tsa bongaka. E khutlisitsoe ho https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx ka la 12 Pulungoana 2020.
Dwivedi, Ramya. "Vitamin C and COVID-19: A Review." News medical. November 12, 2020. .
Dwivedi, Ramya. "Vitamin C and COVID-19: A Review." News medical. https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx. (Accessed on November 12, 2020).
Dwivedi, Ramya. 2020. "Vitamin C and COVID-19: A Review." News-Medical, browsed on November 12, 2020, https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx.
Puisanong ena, Moprofesa Paul Tesar le Kevin Allan ba phatlalalitse litaba ho likoranta tsa litaba tsa bongaka mabapi le hore na maemo a tlase a oksijene a senya boko joang.
Puisanong ena, Dr. Jiang Yigang o buile ka li-ACROBiosystem le boiteko ba eona ba ho loants'a COVID-19 le ho fumana liente Potsong
ena ea lipotso, News-Medical e buile ka nts'etsopele le semelo sa lithibela-mafu tsa monoclonal le David Apiyo, mookameli ea phahameng oa likopo ho Sartorius AG.
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