I-Vitamin C, ekwabizwa ngokuba yi-ascorbic acid, sisondlo esinyibilikayo esibalulekileyo emanzini. Abantu nezinye izilwanyana (ezinje ngee-primates, iihagu) zixhomekeke ku-vitamin C kulwabiwo lweziqhamo kunye nemifuno (ipepile ebomvu, iorenji, istrawberry, ibroccoli, imango, ilamuni). Indima enokubakho ye-vitamin C ekuthinteleni nasekuphuculeni usulelo kuye kwaqatshelwa kuluntu lwezonyango.
I-Ascorbic acid ibalulekile ekuphenduleni komzimba. It has anti-ukudumba, immunomodulatory, antioxidant, anti-thrombosis kunye iipropati anti-wentsholongwane.
Vitamin C seems to be able to regulate the host's response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus is the causative factor of the 2019 coronavirus disease (COVID-19) pandemic, especially It is in a critical period. In a recent comment published in Preprints*, Patrick Holford et al. Solved the role of vitamin C as an auxiliary treatment for respiratory infections, sepsis and COVID-19.
Eli nqaku lixoxa ngendima enokubakho ye-vitamin C ekuthinteleni inqanaba elibalulekileyo le-COVID-19, izifo ezosulelayo zokuphefumla kunye nezinye izifo ezikruthayo. Ukuxhaswa kwe-Vitamin C kulindeleke ukuba ibe yinto yokukhusela okanye yokwelapha i-COVID-19 yokulungisa ukungaphumeleli okubangelwa sesi sifo, ukunciphisa uxinzelelo lwe-oxidative, ukuphucula imveliso ye-interferon kunye nokuxhasa iziphumo ezichasayo ze-glucocorticoids.
Ukugcina amanqanaba esiqhelo eplasma kubantu abadala kwi-50 µmol / l, i-vitamin C yedosi yamadoda yi-90 mg / d kwaye eyabafazi 80 mg / d. Kwanele ukukhusela isikhumba (isifo esibangelwa kukunqongophala kukavithamini C). Nangona kunjalo, eli nqanaba alonelanga ukuthintela ukubonakaliswa kwintsholongwane kunye noxinzelelo lomzimba.
Therefore, the Swiss Nutrition Society recommends supplementing each person with 200 mg of vitamin C-to fill the nutritional gap of the general population, especially adults 65 years and older. This supplement is designed to strengthen the immune system. "
Phantsi koxinzelelo lomzimba, amanqanaba e-vitamin C e-serum yabantu ehla ngokukhawuleza. Umxholo we-serum vitamin C wezigulana ezibhedlele yi-µ11µmol / l, kwaye uninzi lwazo luneengxaki zokuphefumla, i-sepsis okanye i-COVID-19 ebukhali.
Izifundo ezahlukeneyo ezivela kwihlabathi liphela zibonisa ukuba amanqanaba asezantsi e-vithamini C aqhelekile kwizigulana ezigula kakhulu esibhedlele ezinesifo sokuphefumla, inyumoniya, i-sepsis kunye ne-COVID-19-eyona nkcazo inokwenzeka kukusetyenziswa kwemetabolic.
Uhlalutyo lwe-meta lubonakalise oku kuqaphelekayo: 1) Ukongezwa kweVitamin C kunokuwunciphisa kakhulu umngcipheko wenyumoniya, 2) Uphando lwasemva kokubhubha emva kokubhubha kwi-COVID-19 lubonise inyumoniya yesibini, kunye ne-3) Ukusilela kweVitamin C kubalwa inani labantu inyumoniya 62%.
I-Vitamin C inefuthe elibalulekileyo le-homeostatic njenge-antioxidant. Kuyaziwa ngokuba nomsebenzi wokubulala intsholongwane ngokuthe ngqo kwaye kunokunyusa imveliso ye-interferon. Inezinto ezisebenzayo kwiinkqubo zomzimba ezingaphakathi kunye neziguqukayo. UVitamin C unciphisa iintlobo zeoksijini ezisebenzayo (iROS) kunye nokudumba ngokunciphisa ukwenziwa kweNF-κB.
SARS-CoV-2 down-regulates the expression of type 1 interferon (the host's main antiviral defense mechanism), while ascorbic acid up-regulates these key host defense proteins.
Isigaba esibalulekileyo se-COVID-19 (ngesiqhelo isigaba esibulalayo) senzeka ngexesha lokuveliswa ngokugqithisileyo kwee-cytokines ezinamandla kunye neekhemokines. Oku kukhokelele kuphuhliso lokusilela kwamalungu amaninzi. Inxulumene nokufuduka kunye nokuqokelelwa kwee-neutrophils kwi-lung interstitium kunye ne-bronchoalveolar cavity, eyokugqibela isisigqibo esiphambili se-ARDS (Acute Respiratory Distress Syndrome).
Uxinzelelo lwe-ascorbic acid kwiincindi ze-adrenal kunye ne-pituitary gland iphindwe kathathu ukuya kwelishumi ngaphezulu kunalo naliphi na elinye ilungu. Phantsi koxinzelelo lomzimba (ukukhuthazwa yi-ACTH) iimeko kubandakanya ukubonakaliswa yintsholongwane, ivithamin C ikhutshwa kwi-adrenal cortex, ibangela amanqanaba eplasma ukuba ande kahlanu.
I-Vitamin C inokuphucula imveliso ye-cortisol, kunye nokunyusa isiphumo sokukhusela ukuvuvukala kunye nesiphelo se-cell endothelial ye-glucocorticoids. I-Exo native glucocorticoid steroids kuphela kweziyobisi eziqinisekisiweyo zokunyanga i-COVID-19. I-Vitamin C sisiphumo esikhuthazayo esinamadlala amaninzi, esidlala indima ebalulekileyo ekuphenduleni impendulo yoxinzelelo lwe-adrenal cortex (ngakumbi i-sepsis) kunye nokukhusela i-endothelium kumonakalo we-oxidative.
Ukuthatha ingqalelo ivithamin C kwimikhuhlane-ukunciphisa ixesha, ubungqongqo kunye nokuphindaphindeka kokuthatha umkhuhlane ivithamin C kunganciphisa utshintsho ukusuka kusulelo oluncinci ukuya kwixesha elibalulekileyo le-COVID-19.
Kuqatshelwe ukuba ukongezwa kweevithamini C kunganciphisa ubude bokuhlala e-ICU, kunciphise ixesha lokungenisa umoya kwizigulana ezigula kakhulu ezine-COVID-19, kunye nokunciphisa izinga lokufa kwabaguli be-sepsis abafuna unyango kunye ne-vasopressors.
Ukuthathela ingqalelo iimeko ezahlukeneyo zorhudo, amatye kwizintso kunye nokusilela kwezintso ngexesha leedosi eziphezulu, ababhali baxoxa ngokhuseleko lokulawulwa komlomo kunye nokufakwa ngaphakathi kuVithamin C. Kunokucetyiswa ukuba kukhethwe idosi ekhuselekileyo yexeshana elifutshane (2-8 g / ngosuku) ngononophelo phepha iidosi eziphezulu kubantu abanembali yamatye ezintso okanye isifo sezintso). Ngenxa yokuba inyibilikiswa ngamanzi, inokukhutshelwa ngaphakathi kweeyure ezimbalwa, ke ubukhulu bexesha lokulinganisa kubalulekile ukugcina amanqanaba egazi afanelekileyo ngexesha losulelo olusebenzayo.
Njengoko sonke sisazi, ivithamin C inokuthintela usulelo kunye nokuphucula ukuphendula komzimba. Ingakumbi ibhekisa kwinqanaba elibalulekileyo le-COVID-19, ivithamin C idlala indima ebalulekileyo. Ihlisa-ilawula isivunguvungu se-cytokine, ikhusela i-endothelium kumonakalo we-oxidative, idlala indima ebalulekileyo kulungiso lwethishu, kwaye iphucula ukuphendula komzimba kwizifo.
Umbhali ucebisa ukuba izongezo ze vithamin C kufuneka zongezwe yonke imihla ukukhuthaza amaqela anobungozi aphezulu anokusweleka okuphezulu kwe-COVID-19 kunye nokusilela kwe vithamin C. Kuya kufuneka bahlale beqinisekisa ukuba ivithamin C yanele kwaye yonyusa idosi xa intsholongwane isulelekile, ukuya kuthi ga kwi-6-8 g / ngosuku. Inani lezifundo ezihambelana nedosi ezixhomekeke kudosi ziyaqhubeka kwihlabathi liphela ukuqinisekisa indima yayo ekupheliseni i-COVID-19 kunye nokuqonda ngcono indima yayo njengonyango olunokubakho.
Ukuprinta kuya kupapasha iingxelo zenzululwazi zokuqala ezingakhange ziphononongwe ngoontanga, kwaye ke ngoko akufuneki kuthathelwe ingqalelo njengokukuko, ukukhokela ukwenziwa kwezonyango / indlela yokuziphatha enxulumene nempilo okanye kuthathelwa ingqalelo ulwazi oluchanekileyo.
Iimpawu: isifo sokuphefumla esiqatha, anti-inflammatory, antioxidant, ascorbic acid, igazi, broccoli, chemokine, coronavirus, coronavirus isifo COVID-19, corticosteroid, cortisol, cytokine, cytokine, diarrhea, frequency, Glucocorticoids, hormone, immune immune, immune Inkqubo, ukudumba, ukuphambana, izintso, isifo sezintso, ukusilela kwezintso, ukusweleka, ukutya, uxinzelelo lwe-oxidative, ubhubhane, inyumoniya, ukuphefumla, i-SARS-CoV-2, iscurvy, Sepsis, isifo sokuphefumla esiqatha, isifo esiqatha sokuphefumla, istrawberry, uxinzelelo , Isifo, imifuno, intsholongwane, ivithamin C
Ramya une-PhD. IPune National Laboratory (CSIR-NCL) ifumene i-PhD kwi-Biotechnology. Umsebenzi wakhe ubandakanya ukusebenza kwee-nanoparticles ezineemolekyuli ezahlukeneyo zomdla webhayoloji, ukufunda iinkqubo zokuphendula kunye nokwakha usetyenziso oluluncedo.
UDwivedi, uRamya. (2020, Okthobha 23). I-Vitamin C kunye ne-COVID-19: Uphengululo. Iindaba zonyango. Ukufunyanwa kwi-https: //www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx ngo-Novemba 12, 2020.
Dwivedi, Ramya. "Vitamin C and COVID-19: A Review." News medical. November 12, 2020. .
Dwivedi, Ramya. "Vitamin C and COVID-19: A Review." News medical. https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx. (Accessed on November 12, 2020).
Dwivedi, Ramya. 2020. "Vitamin C and COVID-19: A Review." News-Medical, browsed on November 12, 2020, https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx.
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