Vitamin C, inozivikanwawo se ascorbic acid, chinhu chakakosha chinogadziriswa nemvura. Vanhu nedzimwe mhuka (senge nyani, nguruve) zvinoenderana ne vhitamini C mune chikafu chinopa michero nemiriwo (tsvuku tsvuku, orenji, sitirobhu, broccoli, mango, ndimu). Basa rinogona kuvepo revhitamini C mukudzivirira uye kugadzirisa hutachiona kwakazivikanwa munharaunda yekurapa
Ascorbic acid yakakosha kumhinduro yekuzvidzivirira. Iyo ine yakakosha inorwisa-kuzvimba, immunomodulatory, antioxidant, anti-thrombosis uye anti-hutachiona zvivakwa.
Vitamin C seems to be able to regulate the host's response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus is the causative factor of the 2019 coronavirus disease (COVID-19) pandemic, especially It is in a critical period. In a recent comment published in Preprints*, Patrick Holford et al. Solved the role of vitamin C as an auxiliary treatment for respiratory infections, sepsis and COVID-19.
Chinyorwa ichi chinokurukura iro rinogona kuve basa revhitamini C mukudzivirira danho rakakomba reCOVID-19, hutachiona hwekupemha zvakanyanya uye zvimwe zvirwere zvinoputira. Vitamin C yekuwedzera inotarisirwa kuve inodzivirira kana yekurapa mumiririri weECVID-19-kugadzirisa kushomeka kunokonzerwa nechirwere, kudzora kushushikana kweiyo oxidative, kuwedzera kugadzirwa kwe interferon uye kutsigira inorwisa-kupisa mhedzisiro yeglucocorticoids.
Kuti uchengetedze zvakajairika plasma mazinga muvanhu vakuru pa50 µmol / l, iyo vhitamini C muyero wevarume ndeye 90 mg / d uye yevakadzi 80 mg / d. Izvi zvakakwana kudzivirira scurvy (chirwere chinokonzerwa nekushaikwa kwevhitamini C). Zvisinei, iyi nhanho haina kukwana kudzivirira hutachiona hwehutachiona uye kushushikana kwepanyama.
Therefore, the Swiss Nutrition Society recommends supplementing each person with 200 mg of vitamin C-to fill the nutritional gap of the general population, especially adults 65 years and older. This supplement is designed to strengthen the immune system. "
Pasi pemamiriro ekushushikana kwemuviri, huwandu hwevanhu serum vhitamini C inoderera nekukurumidza. Iyo serum vhitamini C yemukati mevarwere vari muchipatara ndeye -11µmol / l, uye mazhinji acho anotambura neacute yekufema hutachiona, sepsis kana yakaoma COVID-19.
Mhando dzakasiyana dzezvidzidzo kubva kumativi epasirese zvinoratidza kuti yakaderera vhitamini C mazinga akajairika mune vanorwara zvakanyanya muchipatara varwere vane mweya wekufema, mabayo, sepsis uye COVID-19-iyo ingangodaro tsananguro inowedzera kushandiswa kwemetabolism.
Iyo meta-ongororo yakaratidza zvinotevera zvinotevera: 1) Vitamin C yekuwedzera inogona kudzora zvakanyanya njodzi yemabayo, 2) Kuongorora kwekufa-kufa mushure mekufa kubva kuCOVID-19 kwakaratidza pneumonia yechipiri, uye 3) Kushomeka kweVitamin C kwakaverengera huwandu hwevanhu mabayo 62%.
Vitamin C ine yakakosha homeostatic mhedzisiro se antioxidant. Inozivikanwa kuva nehutachiona hwehutachiona chaihwo uye inogona kuwedzera kugadzirwa kweiyo interferon. Iyo ine maitiro ekugadzirisa mune ese ari maviri uye anogadzikana immune immune. Vitamin C inoderedza inoshanda yeoksijeni marudzi (ROS) uye kuzvimba nekuderedza kumisikidza kweNF-κB.
SARS-CoV-2 down-regulates the expression of type 1 interferon (the host's main antiviral defense mechanism), while ascorbic acid up-regulates these key host defense proteins.
Chikamu chakakomba che COVID-19 (kazhinji chikamu chinouraya) chinoitika panguva yekuwedzeredza kweanoshanda epro-anogumbura cytokines uye chemokines. Izvi zvakakonzera kukura kweakawanda nhengo kutadza. Izvo zvine chekuita nekutama uye kuunganidzwa kwemautrophils mumapapu interstitium uye bronchoalveolar mhango, iyo yekupedzisira ichiva kiyi inosarudzika yeARDS (Acute Respiratory Distress Syndrome).
Iko kusungwa kwe ascorbic acid mune adrenal gland uye pituitary gland kwakapetwa katatu kusvika kagumi zvakapetwa pane chero imwe nhengo. Pasi pesimba kushushikana (ACTH kukurudzira) mamiriro anosanganisira kutapukirwa nehutachiona, vhitamini C inoburitswa kubva kune adrenal cortex, zvichikonzera mwero weplasma kuwedzera kashanu.
Vitamin C inogona kusimudzira kugadzirwa kwecortisol, uye kusimudzira anti-kupisa uye endothelial maseru ekudzivirira mhedzisiro yeglucocorticoids Exogenous glucocorticoid steroids ndiyo chete mishonga yakaratidza kuti inorapa COVID-19. Vitamin C ndeye yakawanda-mhedzisiro inosimudzira mahormone, iyo inoita basa rakakosha mukugadzirisa iyo adrenal cortex kushushikana kupindura (kunyanya sepsis) uye kudzivirira iyo endothelium kubva kukuvara kweiyo oxidative.
Tichifunga nezve zvinoitika zvevitamini C pazvikosho-kudzikamisa iyo nguva, kuomarara uye kuwanda kwefivha-kutora vhitamini C kunogona kudzora shanduko kubva kuhutachiona hushoma kuenda kune yakaoma nguva yeCOVID-19.
Izvo zvakaonekwa kuti kuwedzerwa kwevhitamini C kunogona kupfupisa kureba kwekugara muICU, kupfupisa nguva yekufefeterwa kwevanorwara zvakanyanya vane COVID-19, uye kudzikisa huwandu hwekufa kwevarwere ve sepsis vanoda kurapwa nevasopressor.
Tichifunga nezve mamiriro akasiyanasiyana emanyoka, itsvo mabwe uye kukundikana kweitsvo panguva yakakwira madhizaini, vanyori vakakurukura nezvekuchengetedzwa kwemuromo uye intravenous manejimendi yevhitamini C. nyatso chengetedza mizinga yakakura kune vanhu vane nhoroondo yeitsvo mabwe kana chirwere cheitsvo) Nekuti inonaya mvura, inogona kuburitswa mukati memaawa mashoma, saka kuwanda kwesero kwakakosha kuchengetedza huwandu hweropa hwakakwana panguva yehutachiona hunoshanda.
Sezvo isu tese tichiziva, vhitamini C inogona kudzivirira hutachiona uye nekuvandudza immune mhinduro. Kunyanya kutaura nezvedanho rakakomba re COVID-19, vhitamini C inoita basa rakakosha. Iyo pasi-inogadzirisa iyo cytokine dutu, inodzivirira iyo endothelium kubva kukuvara kweiyo oxidative, inoita basa rakakosha mukugadzirisa matishu, uye inovandudza mhinduro yemumuviri kuzvirwere.
Munyori anokurudzira kuti vhitamini C inowedzera inofanirwa kuwedzerwa zuva rega rega kukurudzira mapoka ane njodzi ane huwandu hwakanyanya hweCCVID-19 kufa uye kushomeka kwevhitamini C. Ivo vanofanirwa kugara vaine chokwadi chekuti vhitamini C inokwana uye nekuwedzera muyero kana hutachiona hwatapukirwa, kusvika pa6-6 g / zuva. Huwandu hwehuwandu hwevhitamini-inotarisirwa nevhitamin C cohort zvidzidzo zviri kuenderera pasirese kusimbisa basa rayo pakubvisa COVID-19 uye kuti unzwisise zvirinani basa rayo sekugona kwekurapa.
Prprints ichaburitsa yekutanga mvumo yesainzi iyo isina kuongororwa-vezera, uye nekudaro haifanire kutariswa seyakajeka, ichitungamira kiriniki maitiro / maitiro ane chekuita nezvehutano kana kufungidzirwa seyakajeka ruzivo.
Matagi: acute kufema kunetseka syndrome, anti-kupisa, antioxidant, ascorbic acid, ropa, broccoli, chemokine, coronavirus, coronavirus chirwere COVID-19, corticosteroid, cortisol, cytokine, cytokine, manyoka, frequency, Glucocorticoids, mahormone, immune immune, immune system, kuzvimba, kupindirana, itsvo, itsvo chirwere, itsvo kutadza, kufa, kudya kunovaka muviri, oxidative kusagadzikana, denda, mabayo, kufema, SARS-CoV-2, scurvy, Sepsis, chirwere chakasimba chekufema, chakanyanya kufema kufema chirwere, sitiroberi, kushushikana , syndrome, muriwo, hutachiona, vhitamini C
Ramya ane PhD. Pune National Chemical Laboratory (CSIR-NCL) yakagamuchira PhD muBiotechnology. Basa rake rinosanganisira kushanda nanoparticles ane akasiyana mamorekuru ehupenyu kufarira, kudzidza maitiro maitiro uye kuvaka anoshanda mafomu.
Dwivedi, Ramya. (2020, Gumiguru 23). Vitamin C uye COVID-19: Ongororo. Nhau dzekurapa. Kudzorerwa kubva ku https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx musi waNovember 12, 2020.
Dwivedi, Ramya. "Vitamin C and COVID-19: A Review." News medical. November 12, 2020. .
Dwivedi, Ramya. "Vitamin C and COVID-19: A Review." News medical. https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx. (Accessed on November 12, 2020).
Dwivedi, Ramya. 2020. "Vitamin C and COVID-19: A Review." News-Medical, browsed on November 12, 2020, https://www.news-medical.net/news/20201023/Vitamin-C-and-COVID-19-A-Review.aspx.
Mune iyi bvunzurudzo, Muzvinafundo Paul Tesar naKevin Allan vakaburitsa nhau kuvanhau venhau vezvekurapa nezvekuti mwero weokisijeni wakaderera ungakanganisa sei uropi
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