Khoom Nthuav dav
Cov khoom lag luam
| Khoom npe |
Cefotaxime Sodium |
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| CAS: |
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| MF: |
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| MW: |
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| EINECS: |
264-915-9 |
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- Cefotaxime (Claforan) yog thawj-tiam thib peb-tiamcephalosporin. Nws muaj cov dej num ua tau zoo tshaj plaws-tawm tsam tiv thaiv kab mob Gram-positive thiab Gramnegativeaerobic thiab anaerobic. Nws yog ntau tshaj activethan moxalactam tawm tsam Gram-zoo yam muaj sia. Ntau yam β lactamase – uas tsim cov kab mob rau cov kab mob ua rau muaj kev nyuaj siab ntawm cefotaxime, suav nrog N. gonorrhoeae, Klebsiella spp., H. influenzae, S. aureus, thiab E. cloacae. Qee, tab sis tsis yog txhua txhua, kab mob Pseudomonas yog qhov nkag siab. Enterococci thiab Listeriamonocytogenes yuav tiv taus.
Lub syn-isomer ntawm cefotaxime yog qhov ua haujlwm ntau dua los tiv thaiv isomer tawm tsam ase-lactamase – ua rau cov kab mob.Qhov potency qhov sib txawv yog, hauv qee qhov, vim hais tias ntau dua ntawm cov syn-isomer rau qhov kev txiav txim ntawm β-lactamases.Qhov siab dua ntawm syn-isomer rau PBPs, txawm li cas los xij, nws kuj tseem tuaj yeem ua.
Cefotaxime metabolized nyob rau ib feem ntawm qhov tsis muaj zog desacetylmetabolite. Kwv yees li 20% ntawm metaboliteand 25% ntawm niam txiv tshuaj yog tawm hauv cov zis. Theparent tshuaj tau mus txog cov kua tshuaj cerebrospinal hauv cov tshuaj txaus kom zoo rau kev kho mob rau daim npluag qhwv lub cev.Lwm yam ntawm cefotaxime sodium yuav tsum siv nyob rau hauv 24hours. Yog tias muab cia, lawv yuav tsum nyob hauv tub yees. Cov dej txias daws teeb meem siv tau ntev li 10 hnub.
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cov qauv txheej txheem: 
Cov khoom paub meej muaj raws li hauv qab no:
| Zog: |
dawb los yog dawb nrog lub ntsej muag daj ua kom daj hmoov |
| Solubility: |
dawb do rau hauv dej, sparingly soluble hauv methanol |
| Kev hloov kho qhov muag tshwj xeeb: |
+58 º ~ +64 º |
| Kev nqus tshwj xeeb: |
360 ~ 390 |
| Xim ntawm cov tshuaj: |
0.2 |
| Poob rau qhuav: |
≤3.0% |
| PH: |
4.5 ~ 6.5 |
| Pom ntawm cefotaxime: |
916μg / mg ~ 964 μg / mg |
| Yam khoom sib xws: |
| Tus neeg impurity: |
≤1.0% |
| Tag nrho impurity: |
≤3.0% |
| Muaj nuj nqi: |
- Cefotaxime sodium sterile yog lub cim thib peb ntawm ib nrab hluavtaws cephalosporin nrog cov kev ua haujlwm muaj zog tiv thaiv kab mob Gram-tsis zoo, tshwj xeeb tshaj yog. Enterobacter. Raws li rau Escherichia coli, mob khaub thuas bacillus, Klebsiella mob ntsws, Proteus mirabilis, thiab Salmonella, nws muaj cov nyhuv muaj zog dua li Cefoperazone.
- Nws yog siv rau kev kis mob ntawm txoj hlab ua pa, mob txeeb zig, pob txha thiab pob qij txha, tawv nqaij thiab cov nqaij mos, mob plab, ua kom lub plab zom mov, mob plab, ua kom lub ntsej muag, lub ntsej muag thiab lwm qhov los ntawm cov kab mob rhiab. Nws kuj siv tau rau kev kis mob los ntawm kev kub hnyiab thiab raug mob, nrog rau sepsis thiab nruab nrab kis mob.
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Peb lwm cov khoom loj:
Yav dhau los:
Cefradine
Tom ntej:
Ranitidine
