l: I-Antibiotic Ehlukahlukene Yezicelo Ezihlukahlukene

Emkhakheni wemithi elwa namagciwane, i-Oxytetracycline HCl iye yavela njengenhlanganisela ebaluleke kakhulu ngenxa yezindawo zayo zokulwa namagciwane ezibanzi kanye nokuguquguquka kwezinhlelo zokusebenza ezihlukahlukene. Muva nje, le khompiyutha ithole ukunakwa okubalulekile kuyo yomibili imikhakha yesayensi kanye nezimboni, okuyenza ibe isihloko socwaningo oluqinile kanye nentshisekelo yezohwebo.

I-Oxytetracycline HCl, nefomula yayo yamakhemikhali ethi C22H24N2O9·HCl kanye nesisindo sengqamuzana esingu-496.89, iyimpushana eyikristalu ephuzi ezinzile emoyeni kodwa ingaba mnyama ngaphansi kokuchayeka elangeni. Lesi sibulala-magciwane singokwesigaba se-tetracycline semithi nemisebenzi ngokuvimbela ukwakheka kwamaprotheni ngokuvimbela ukuboshwa kwe-aminoacyl-tRNA ku-30S ribosomal subunit. Umsebenzi wayo we-spectrum ebanzi uhlanganisa kokubili amagciwane e-Gram-positive kanye ne-Gram-negative, okuyenza ibe ithuluzi elibalulekile kukho kokubili ucwaningo nezinhlelo zokusebenza ezingokoqobo.

Imithi elwa namagciwane iyaziwa ngokusebenza kwayo ezimeni ezehlukene zempilo yezilwane. Ucwaningo olwanyatheliswa kuyi-Poultry Science ngo-1977 lwaphenya nge-pharmacodynamics ye-oxytetracycline HCl ezinkukhu. Ucwaningo lwathola ukuthi izindlela zokulawula ngomlomo nange-intramuscular zazisebenza kahle, nemizila ye-intramuscular kanye ne-subcutaneous eholela emazingeni aphezulu ezicubu. Ngokuphawulekayo, amasampula ezinso nesibindi ayequkethe amazinga aphezulu omuthi, kuyilapho amazinga amaphaphu neserum ngokuvamile ayephansi. Lolu cwaningo lugcizelela ukubaluleka kwemizila yokuphatha efanele ekuqinisekiseni ukulethwa kwezidakamizwa ngempumelelo.

Ngaphezu kokusebenza kwayo kwezempilo yezilwane, i-Oxytetracycline HCl iphinde isetshenziswe kakhulu ekudleni kwezolimo ukuze kuthuthukiswe ukukhula nokuvimbela izifo. Isibonelo, ekudleni kwezingulube, kusetshenziswa ngemithamo ethile kuye ngeminyaka yezingulube. Ngokufanayo, ekudleni kwenkukhu, yengezwa ukuze kuthuthukiswe ukukhula nempilo, nakuba kunemingcele ngesikhathi sokubeka. Lezi zinhlelo zokusebenza zibonisa ukusebenza kahle kwenhlanganisela nokuguquguquka kwemfuyo.

Ukukhiqizwa kwezimboni kanye nokutholakala kwezohwebo kwe-Oxytetracycline HCl kukhule kakhulu. Izinkampani eziningana, njenge-Shanghai Zeye Biotechnology Co., Ltd., zinikeza lo mkhiqizo ngemininingwane ehlukahlukene kanye nenani. Lezi zinkampani ngokuvamile ziqinisekisa amazinga aphezulu okuhlanzeka, ngokuvamile adlula u-95% (HPLC), futhi zinikeza imininingwane yomkhiqizo enemininingwane, okuhlanganisa izinombolo ze-CAS, izisindo zamangqamuzana, nezimo zokulondoloza. Ngokusebenza okugxilile ocwaningweni nasekuthuthukisweni, lezi zinkampani ngokuqhubekayo zilwela ukuthuthukisa ikhwalithi yomkhiqizo futhi zandise imigqa yemikhiqizo yazo ukuze zihlangabezane nezidingo zemakethe eziguqukayo.

Ukwanda kokutholakala kwezentengiselwano kwe-Oxytetracycline HCl nakho kuqhubekisele phambili ucwaningo ezinhlelweni zayo ezingase zibe khona ngaphezu kokusetshenziswa kwendabuko. Ocwaningweni lwe-biochemical, i-compound isebenza njengethuluzi elibalulekile lokutadisha amaprotheni synthesis kanye nokusebenza kwe-ribosomal. Ikhono layo lokukhomba ngokuqondile ama-subunits e-ribosomal ebhaktheriya kuyenza ibe ikhandidethi elikhangayo lokuqhubeka nokuthuthuka emkhakheni wokutholwa kwezidakamizwa ezilwa namagciwane.

Ngaphezu kwalokho, ukusetshenziswa kwe-Oxytetracycline HCl ekuhlolweni kwe-electrophoresis kukhombisa ukusetshenziswa kwayo ocwaningweni lwebhayoloji yamangqamuzana. Ukusebenzisana kwayo okukhethekile ne-DNA kanye namabhafa e-electrophoresis kuyenza ibe isisetshenziswa esiwusizo sokutadisha amaphethini okufuduka kwe-DNA kanye nokwakheka kwamabhendi. Lezi zifundo zinomthelela ekuthuthukiseni ukuqonda kwethu izindlela zamangqamuzana futhi zenze kube lula ukuthuthukiswa kwamasu amasha okuxilonga.

Sengiphetha, i-Oxytetracycline HCl ime njengobufakazi bokuthuthuka okuqhubekayo kanye nokuthuthuka kobuchwepheshe bama-antibiotic. Umsebenzi wayo we-antibacterial we-spectrum obanzi, ohambisana nokuhlukahluka kwawo ezinhlelweni ezihlukahlukene, ugcizelela ukubaluleka kwawo kukho kokubili ucwaningo nezilungiselelo ezingokoqobo. Njengoba izinkampani ziqhubeka nokuthuthukisa izindlela zokukhiqiza nokwandisa ukunikezwa kwemikhiqizo, ukusetshenziswa okungenzeka kwe-Oxytetracycline HCl kungenzeka kukhule, kuqinise kakhulu isimo sayo njengesisekelo emkhakheni wemithi elwa namagciwane.