I-Metronidazole: I-Antibiotic Ehlukahlukene Esebenzisa Izicelo Ezibanzi

I-Metronidazole, isibulala-magciwane esisekelwe ku-nitroimidazole esisebenza ngomlomo, sesivele njenge-ejenti yokwelapha eyinhloko ekwelapheni izifo eziningi. Lesi sidakamizwa saziwa ngokukwazi ukungena emgodleni wobuchopho begazi, lesi sidakamizwa sibonise ukusebenza kahle okuphawulekayo ekubhekaneni nezimo ezihlukahlukene zezokwelapha.

I-Metronidazole iphumelela kakhulu ngokumelene nama-anaerobic microorganisms. Ibonisa umsebenzi ovimbelayo ngokumelene ne-anaerobic protozoa efana ne-Trichomonas vaginalis (ebangela i-trichomoniasis), i-Entamoeba histolytica (ebhekene ne-amoebic dysentery), i-Giardia lamblia (ebangela i-giardiasis), ne-Balantidium coli. Ucwaningo lwe-in vitro lubonise umsebenzi walo wokubulala amagciwane ngokumelene namagciwane e-anaerobic ekugxilweni kuka-4-8 μg/mL.

Emkhakheni wezokwelapha, i-Metronidazole inqunyelwe ukwelapha i-trichomoniasis yangasese, izifo ze-amoebic zamathumbu kanye nezingosi zangaphandle, kanye ne-leshmaniasis yesikhumba. Iyasebenza futhi ekulawuleni ezinye izifo ezifana ne-sepsis, i-endocarditis, i-empyema, amathumba amaphaphu, izifo zesisu, izifo ze-pelvic, izifo zabesifazane, izifo zamathambo namalunga, i-meningitis, amathumba ebuchosheni, izifo zesikhumba nezicubu ezithambile, i-pseudomembranous colitis, i-Helicobacter-associates pyloptic gastroenteritis.

Naphezu kwezinzuzo zayo zokwelapha, i-Metronidazole ingabangela ukusabela okungekuhle kwezinye iziguli. Ukuphazamiseka okuvamile kwamathumbu kuhlanganisa isicanucanu, ukuhlanza, i-anorexia, nobuhlungu besisu. Izimpawu ze-neurological ezifana nekhanda elibuhlungu, isiyezi, nokuphazamiseka kwezinzwa ngezikhathi ezithile kanye ne-neuropathy eminingi ingase ivele. Ezimweni ezingavamile, iziguli zingase zibe nokuqubuka, ukuqunjelwa, pruritus, cystitis, ubunzima bokuchama, ukunambitheka kwensimbi emlonyeni, kanye ne-leukopenia.

Ochwepheshe bezempilo bagcizelela ukubaluleka kokuqapha iziguli eduze ngesikhathi sokwelashwa kwe-Metronidazole ukuze kuqinisekiswe ukuphepha nokusebenza ngempumelelo. Ngomsebenzi wayo obanzi kanye nokusebenza ngempumelelo okuqinisekisiwe, i-Metronidazole iyaqhubeka nokuba isengezo esibalulekile ku-arsenal ye-antimicrobial.