l: I-Antibiotic eNxulumene neMisebenzi eyahlukeneyo

Kwindawo ye-antibiotics, i-Oxytetracycline HCl iye yavela njengento ebalulekileyo ngenxa yeempawu zayo ezibanzi zokulwa ne-antibacterial kunye nokuguquguquka kwizicelo ezahlukeneyo. Kutshanje, le khompawundi ifumene ingqwalasela ebalulekileyo kuluntu lwenzululwazi kunye namacandelo ezoshishino, oko kuyenza ibe ngumxholo wophando olungqongqo kunye nomdla worhwebo.

I-Oxytetracycline HCl, kunye nefomula yayo yeekhemikhali C22H24N2O9 · HCl kunye ne-molecular weight 496.89, i-yellow crystalline powder ezinzile emoyeni kodwa ingaba mnyama phantsi kokukhanya kwelanga. Esi sithinteli-ntsholongwane sikwiklasi ye-tetracycline yamachiza kunye nemisebenzi ngokuthintela iprotheni synthesis ngokuthintela ukubophelela kwe-aminoacyl-tRNA kwi-30S ribosomal subunit. Umsebenzi wayo obanzi ubandakanya iibhaktheriya ze-Gram-positive kunye ne-Gram-negative, nto leyo eyenza ibe sisixhobo esixabisekileyo kuzo zombini uphando kunye nokusetyenziswa okusebenzayo.

Isithinteli-ntsholongwane siyaziwa ngokusebenza kwayo kwiimeko ezahlukeneyo zempilo yezilwanyana. Uphononongo olupapashwe kwiPoultry Science ngo-1977 luphande nge-pharmacodynamics ye-oxytetracycline HCl kwiinkukhu. Uphando lufumene ukuba zombini iindlela zokulawula ngomlomo kunye ne-intramuscular zazisebenza kakuhle, kunye neendlela ze-intramuscular and subcutaneous ezibangelwa amanqanaba aphezulu e-tissue. Ngokucacileyo, iisampulu zezintso kunye nesibindi beziqulathe awona manqanaba aphezulu echiza, ngelixa amanqanaba emiphunga kunye neserum ayephantsi ngokubanzi. Olu phando lugxininisa ukubaluleka kweendlela zolawulo ezifanelekileyo ekuqinisekiseni ukuhanjiswa kweziyobisi okusebenzayo.

Ukongeza kwizicelo zempilo yezilwanyana, iOxytetracycline HCl ikwasetyenziswa kakhulu kwisondlo sezolimo ukukhuthaza ukukhula nokuthintela usulelo. Umzekelo, ekutyeni kweehagu, kusetyenziswa ngokwemilinganiselo ethile ngokuxhomekeke kwiminyaka yeehagu. Ngokufanayo, kwisondlo senkukhu, yongezwa ukunyusa ukukhula kunye nempilo, nangona kukho izithintelo ngexesha lokubeka. Ezi zicelo zibonisa ukusebenza kakuhle kwekhompawundi kunye nokuguquguquka kokufuywa kwezilwanyana.

Imveliso yemizi-mveliso kunye nokufumaneka kwezorhwebo kwe-Oxytetracycline HCl kwande kakhulu. Iinkampani ezininzi, ezinje ngeShanghai Zeye Biotechnology Co., Ltd., zibonelela ngale mveliso kwiinkcukacha ezahlukeneyo kunye nobungakanani. Ezi nkampani ngokuqhelekileyo ziqinisekisa amanqanaba aphezulu okucoceka, ahlala edlula i-95% (HPLC), kwaye anikezela iinkcukacha ezicacileyo zemveliso, kubandakanywa amanani e-CAS, ubunzima be-molecular, kunye neemeko zokugcina. Ngemisebenzi esekelwe kuphando kunye nophuhliso, ezi nkampani zihlala zizama ukuphucula umgangatho wemveliso kunye nokwandisa imigca yemveliso yazo ukuhlangabezana neemfuno zemarike eziguqukayo.

Ukufumaneka korhwebo okwandayo kwe-Oxytetracycline HCl kukwaphembelele uphando kwizicelo zayo ezinokubakho ngaphaya kokusetyenziswa kwemveli. Kuphando lwe-biochemical, ikhompawundi isebenza njengesixhobo esixabisekileyo sokufunda iprotein synthesis kunye nomsebenzi we-ribosomal. Ukukwazi kwayo ukujolisa ngokuthe ngqo kwi-ribosomal subunits zebhaktiriya kuyenza ibe ngumgqatswa onomtsalane wophuhliso olongezelelweyo kwicandelo lokufunyanwa kwechiza le-antibacterial.

Ngaphezu koko, ukusetyenziswa kwe-Oxytetracycline HCl kwiimvavanyo ze-electrophoresis kubonisa ukusetyenziswa kwayo kuphando lwe-biology ye-molecular. Ukusebenzisana kwayo okuthe ngqo kunye ne-DNA kunye ne-electrophoresis buffers yenza ukuba ibe yinto eluncedo yokufunda iipatheni zokufuduka kwe-DNA kunye nokwakheka kweebhendi. Ezi zifundo zinegalelo ekuqhubeleni phambili ukuqonda kwethu iindlela zemolekyuli kunye nokuququzelela uphuhliso lweendlela ezintsha zokuxilonga.

Ukuqukumbela, i-Oxytetracycline HCl ime njengobungqina bokuziphendukela kwemvelo okuqhubekayo kunye nokuqhubela phambili kweteknoloji ye-antibiotic. Umsebenzi wayo we-antibacterial-spectrum obanzi, kunye nokuguquguquka kwayo kwizicelo ezahlukeneyo, igxininisa ukubaluleka kwayo kuphando kunye nezicwangciso ezisebenzayo. Njengoko iinkampani ziqhubeka nokuphucula iindlela zemveliso kunye nokwandisa ukunikezelwa kweemveliso, usetyenziso olunokubakho lwe-Oxytetracycline HCl lunokukhula, luqinise ngakumbi ubume bayo njengelitye lembombo kwicandelo lamayeza okubulala iintsholongwane.