l: Lithibela-mafu tse Fetohang bakeng sa Likopo tse fapaneng

Sebakeng sa lithibela-mafu, Oxytetracycline HCl e hlahile e le motsoako oa bohlokoa ka lebaka la thepa ea eona ea ho thibela likokoana-hloko e pharaletseng le ho feto-fetoha ha mekhoa e mengata ea ho sebelisoa. Haufinyane tjena, komporo ena e hapile tlhokomelo e kholo ho tsoa mekhatlong ea mahlale le mafapha a indasteri, a e etsa taba ea lipatlisiso tse matla le thahasello ea khoebo.

Oxytetracycline HCl, e nang le foromo ea eona ea lik'hemik'hale C22H24N2O9 · HCl le boima ba molek'hule ea 496.89, ke phofo e mosehla ea kristale e tsitsitseng moeeng empa e ka fifala ha e pepesehela letsatsi. Sethibela-mafu sena ke sa sehlopha sa litlhare tsa tetracycline 'me se sebetsa ka ho thibela motsoako oa protheine ka ho thibela ho tlamahanngoa ha aminoacyl-tRNA ho 30S ribosomal subunit. Ts'ebetso ea eona e pharaletseng e akaretsa libaktheria tse ntle tsa Gram-positive le Gram-negative, e leng se etsang hore e be sesebelisoa sa bohlokoa lipatlisisong le lits'ebetsong tse sebetsang.

Sethibela-mafu se tsebahala ka katleho ea sona maemong a fapaneng a bophelo ba liphoofolo. Phuputso e phatlalalitsoeng ho Poultry Science ka 1977 e ile ea batlisisa pharmacodynamics ea oxytetracycline HCl likhoho. Lipatlisiso li fumane hore litsela tsa tsamaiso ea molomo le ea intramuscular li ne li sebetsa hantle, ka litsela tsa intramuscular le subcutaneous tse hlahisang maemo a phahameng a lisele. Haholo-holo, lisampole tsa liphio le sebete li ne li e-na le litekanyetso tse phahameng ka ho fetisisa tsa sethethefatsi, athe boemo ba matšoafo le serum hangata bo ne bo le tlase. Patlisiso ena e totobatsa bohlokoa ba litsela tse nepahetseng tsa tsamaiso ho netefatsa phano e sebetsang ea lithethefatsi.

Ntle le ts'ebeliso ea eona ea bophelo bo botle ba liphoofolo, Oxytetracycline HCl e boetse e sebelisoa haholo lijong tsa temo ho khothaletsa kholo le ho thibela tšoaetso. Mohlala, phepong ea likolobe, e sebelisoa ka litekanyetso tse ikhethileng ho latela lilemo tsa likolobe. Ka mokhoa o ts'oanang, lijong tsa likhoho, li eketsoa ho matlafatsa kholo le bophelo bo botle, ho sa tsotellehe lithibelo nakong ea ho behoa. Ts'ebeliso ena e bonts'a katleho ea motsoako le ho feto-fetoha ha maemo ho ruoeng ha liphoofolo.

Tlhahiso ea indasteri le ho fumaneha ha khoebo ea Oxytetracycline HCl li eketsehile haholo. Likhamphani tse 'maloa, joalo ka Shanghai Zeye Biotechnology Co., Ltd., li fana ka sehlahisoa sena ka litlhaloso le bongata bo fapaneng. Hangata lik'hamphani tsena li netefatsa maemo a phahameng a bohloeki, hangata a fetang 95% (HPLC), 'me a fana ka litlhaloso tse qaqileng tsa sehlahisoa, ho kenyelletsa le linomoro tsa CAS, boima ba limolek'hule, le maemo a polokelo. Ka ts'ebetso e thehiloeng ho lipatlisiso le nts'etsopele, lik'hamphani tsena li lula li leka ho ntlafatsa boleng ba sehlahisoa le ho holisa mekhoa ea bona ea lihlahisoa ho fihlela litlhoko tse ntseng li tsoela pele tsa 'maraka.

Ho eketseha ho fumaneha ha Oxytetracycline HCl khoebong ho boetse ho matlafalitse lipatlisiso mabapi le ts'ebeliso ea eona e ka bang teng ho feta ts'ebeliso ea setso. Lipatlisisong tsa biochemical, motsoako ona o sebetsa e le sesebelisoa sa bohlokoa sa ho ithuta ka protheine synthesis le ts'ebetso ea ribosomal. Bokhoni ba eona ba ho shebisisa li-subunits tsa baktheria tsa ribosomal bo etsa hore e be mokhethoa ea khahlehang bakeng sa nts'etsopele e tsoelang pele lebaleng la ho sibolla lithethefatsi tse thibelang likokoana-hloko.

Ho feta moo, ts'ebeliso ea Oxytetracycline HCl litekong tsa electrophoresis e bonts'a ts'ebeliso ea eona lipatlisisong tsa baeloji ea limolek'hule. Litšebelisano tsa eona tse ikhethileng le DNA le li-buffers tsa electrophoresis li etsa hore e be sesebelisoa sa bohlokoa sa ho ithuta mekhoa ea ho falla ea DNA le libopeho tsa lihlopha. Lithuto tsena li kenya letsoho ho ntlafatseng kutloisiso ea rona ea mekhoa ea limolek'hule le ho thusa ho nts'etsopele ea mekhoa e mecha ea tlhahlobo.

Qetellong, Oxytetracycline HCl e eme e le bopaki ba tsoelo-pele e tsoelang pele le tsoelo-pele ea theknoloji ea lithibela-mafu. Ts'ebetso ea eona ea antibacteria e pharalletseng, hammoho le ho feto-fetoha ha eona lits'ebetsong tse fapaneng, e totobatsa bohlokoa ba eona lipatlisisong le maemong a sebetsang. Ha lik'hamphani li ntse li tsoela pele ho ntlafatsa mekhoa ea tlhahiso le ho atolosa linyehelo tsa lihlahisoa, lisebelisoa tse ka 'nang tsa e-ba teng tsa Oxytetracycline HCl li ka' na tsa hōla, li tiisa boemo ba eona ba ho ba lejoe la motheo lefapheng la lithibela-mafu.