l: A Versatile Antibiotic kune Akasiyana Zvikumbiro

Munzvimbo yemishonga inorwisa mabhakitiriya, Oxytetracycline HCl yakabuda semushonga wakakosha nekuda kwehupamhi-hukuru hwemaantibacterial properties uye kuita zvakasiyana-siyana mumashandisirwo akasiyana. Munguva pfupi yapfuura, komisheni iyi yakawana kutariswa kwakakosha kubva kunharaunda dzesainzi uye maindasitiri, zvichiita kuti ive nyaya yekutsvagisa kwakasimba uye kufarira kwekutengesa.

Oxytetracycline HCl, ine makemikoro ayo C22H24N2O9 · HCl uye molecular huremu hwe 496.89, icrystal crystalline powder inogadzikana mumhepo asi inogona kusviba pasi pekuratidzwa kwezuva. Mushonga unorwisa mabhakitiriya uyu ndeweboka retetracycline remishonga uye rinoshanda nekudzivisa kuumbwa kweprotein kuburikidza nekudzivirira kusungwa kweaminoacyl-tRNA ku30S ribosomal subunit. Basa rayo rakafara-spectrum rinovhara mabhakitiriya eGram-positive uye Gram-negative, zvichiita kuti ive chimbo chakakosha mukutsvakurudza uye kushandiswa kunoshanda.

Mushonga unorwisa mabhakitiriya unozivikanwa nekushanda kwawo mune dzakasiyana siyana hutano hwemhuka. Chidzidzo chakabudiswa muPoultry Science muna 1977 chakaongorora pharmacodynamics ye oxytetracycline HCl muhuku. Tsvagiridzo yacho yakawana kuti nzira dzese dzemumuromo uye intramuscular manejimendi dzaive dzakabudirira, ine intramuscular uye subcutaneous nzira zvichikonzera mazinga akakwirira ematishu. Sezvineiwo, masampuli eitsvo nechiropa aive neakanyanya mazinga emushonga, nepo mazinga emapapu neeserum aiwanzove akaderera. Tsvagiridzo iyi inosimbisa kukosha kwenzira dzakakodzera dzekutonga mukuona kufambiswa kwezvinodhaka kunoshanda.

Pamusoro pekushandisa kwayo kwehutano hwemhuka, Oxytetracycline HCl inoshandiswawo zvakanyanya mukudya kwekurima kukurudzira kukura nekudzivirira zvirwere. Semuyenzaniso, mukudya kwenguruve, inoshandiswa pamiyero chaiyo zvichienderana nezera renguruve. Saizvozvo, mukudya kwehuku, inowedzerwa kuwedzera kukura uye hutano, kunyangwe paine zvirambidzo panguva yekukandira. Zvishandiso izvi zvinoratidza kushanda nesimba kwekomboni uye kuita zvakasiyana-siyana mukupfuya mhuka.

Kugadzirwa kwemaindasitiri uye kuwanikwa kwekutengesa kweOxytetracycline HCl kwawedzera zvakanyanya. Makambani akati wandei, akadai seShanghai Zeye Biotechnology Co., Ltd., anopa chigadzirwa ichi mune zvakasiyana siyana uye huwandu. Aya makambani anowanzo vimbisa kuchena kwemazinga, anowanzopfuura 95% (HPLC), uye anopa akadzama echigadzirwa, kusanganisira nhamba dzeCAS, uremu hwemamorekuru, uye mamiriro ekuchengetedza. Nekushanda kwakadzika midzi mukutsvagisa nekusimudzira, makambani aya anoramba achiedza kukwidziridza mhando yechigadzirwa uye kuwedzera mitsara yechigadzirwa kuti isangane nezvinoda musika.

Kuwedzera kuwanikwa kwekutengesa kweOxytetracycline HCl kwakakurudzirawo tsvakiridzo mune zvingangoita mashandisirwo ayo kupfuura kushandiswa kwechinyakare. Mukutsvagisa biochemical, iyo komputa inoshanda sechinhu chakakosha chekudzidza protein synthesis uye ribosomal basa. Kugona kwayo kunyatso kunanga bhakitiriya ribosomal subunits inoita kuti ive mumiriri anoyevedza wekuwedzera budiriro mumunda wekuwanikwa kwemishonga inorwisa mabhakitiriya.

Uyezve, kushandiswa kweOxytetracycline HCl mukuedza kwe electrophoresis kunoratidza kushandiswa kwayo mukutsvakurudza kwema molecular biology. Kudyidzana kwayo chaiko neDNA uye electrophoresis buffers inoita kuti ive reagent inobatsira yekudzidza DNA migration mapatani uye mabhendi maumbirwo. Zvidzidzo izvi zvinobatsira mukusimudzira kunzwisisa kwedu kwemaitiro emamorekuru uye kufambisa kuvandudzwa kwemaitiro matsva ekuongorora.

Mukupedzisa, Oxytetracycline HCl inomira sechiratidzo chekuenderera mberi kwekushanduka uye kufambira mberi kwemishonga inorwisa mabhakitiriya. Yayo yakakura-spectrum antibacterial chiitiko, pamwe nekuita kwayo kwakasiyana-siyana mumashandisirwo akasiyana-siyana, inosimbisa kukosha kwayo mune zvese tsvagiridzo uye inoshanda marongero. Sezvo makambani arikuramba achiwedzera nzira dzekugadzira uye kuwedzera zvigadzirwa zvinopihwa, zvingango shandiswa zveOxytetracycline HCl zvinogona kukura, zvichisimbisa chimiro chayo sedombo repakona mumunda wemishonga inorwisa mabhakitiriya.