Metronidazole: Mushonga Wakasiyana-siyana une Broad Application

Metronidazole, nitroimidazole-based antibiotic ine chekuita nemuromo, yakabuda semushonga wekurapa mukurapa huwandu hwakawanda hwehutachiona. Inozivikanwa nekugona kwayo kupinda mukati meropa-brain barriers, mushonga uyu wakaratidza kushanda kunoshamisa mukugadzirisa zvirwere zvakasiyana-siyana.

Metronidazole inonyanya kushanda pakurwisa anaerobic microorganisms. Inoratidza inhibitory kuita kurwisa anaerobic protozoa yakadai seTrichomonas vaginalis (inokonzera trichomoniasis), Entamoeba histolytica (inokonzera amoebic dysentery), Giardia lamblia (inokonzera giardiasis), uye Balantidium coli. In vitro zvidzidzo zvakaratidza basa rayo rebhaktericidal kurwisa mabhakitiriya eanaerobic pahuwandu hwe4-8 μg/mL.

Munharaunda yezvokurapa, Metronidazole inorayirwa kurapwa kwevaginal trichomoniasis, zvirwere zveamoebic zvemukati uye nzvimbo dzekunze, uye leshmaniasis yeganda. Inoshandawo mukugadzirisa zvimwe zvirwere zvakadai sepsis, endocarditis, empyema, mapapu abscesses, zvirwere zvemudumbu, zvirwere zvepelvic, zvirwere zvegynecological, zvirwere zvemapfupa uye majoini, meningitis, abscesses europi, ganda uye zvinyoro zvinyoro zvipembenene, pseudomembranous colitis, Helicobacter-associated pyloprise gastroenteritis.

Pasinei nemabhenefiti ayo ekurapa, Metronidazole inogona kukonzera kusagadzikana mune vamwe varwere. Kusagadzikana kwegastrointestinal kwakajairika kunosanganisira kuda kurutsa, kurutsa, anorexia, uye kurwadziwa mudumbu. Neurological zviratidzo zvakadai semusoro, dzungu, uye dzimwe nguva kuvhiringidzika kwekunzwa uye multiple neuropathies zvinogonawo kuitika. Muzviitiko zvisingawanzoitiki, varwere vanogona kusangana nepundu, kuputika, pruritus, cystitis, kuoma kwekuita weti, kuravira kwesimbi mumuromo, uye leukopenia.

Nyanzvi dzehutano dzinosimbisa kukosha kwekutarisisa varwere panguva yeMetronidazole kurapwa kuti ive nechokwadi chekuchengetedza uye kushanda. Nehuwandu hwayo hwakawanda hwekuita uye kushanda kwakasimbiswa, Metronidazole inoramba ichiwedzera kukosha kune antimicrobial arsenal.