l: Antibiyotike itandukanye kuri porogaramu zitandukanye

Mu rwego rwa antibiyotike, Oxytetracycline HCl yagaragaye nkurwego rukomeye kubera imiterere ya antibacterial nini yagutse kandi ikoreshwa muburyo butandukanye. Vuba aha, uru ruganda rwitabiriwe cyane n’umuryango w’ubumenyi n’inganda, bituma ruba ubushakashatsi bukomeye n’inyungu z’ubucuruzi.

Oxytetracycline HCl, hamwe na formulaire ya chimique C22H24N2O9 · HCl hamwe nuburemere bwa molekile ya 496.89, ni ifu ya kristaline yumuhondo ihagaze neza mukirere ariko irashobora kwijimye mugihe izuba riva. Iyi antibiyotike ni iy'urwego rwa tetracycline rw'ibiyobyabwenge n'imikorere ihagarika intungamubiri za poroteyine binyuze mu gukumira guhuza aminoacyl-tRNA na 30S ribosomal subunit. Igikorwa cyacyo cyagutse gikubiyemo Gram-nziza na Gram-mbi ya bagiteri, ikaba igikoresho cyingirakamaro mubushakashatsi no mubikorwa bifatika.

Antibiyotike izwiho gukora neza mubihe bitandukanye byubuzima bwinyamaswa. Ubushakashatsi bwasohotse mu bumenyi bw'inkoko mu 1977 bwakoze iperereza kuri farumasi ya oxytetracycline HCl mu nkoko. Ubushakashatsi bwerekanye ko inzira zo kuyobora mu kanwa no mu mitsi zagize akamaro, hamwe n'inzira zo mu nda ndetse no munsi y'ubutaka bigatuma urwego rwinshi rwimitsi. Ikigaragara ni uko urugero rwimpyiko numwijima rwarimo urwego rwo hejuru rwibiyobyabwenge, mugihe ibihaha na serumu byari bike. Ubu bushakashatsi bushimangira akamaro k'inzira zibishinzwe zikwiye mu gutanga ibiyobyabwenge neza.

Usibye gukoresha ubuzima bw’inyamaswa, Oxytetracycline HCl ikoreshwa cyane mu biryo by’ubuhinzi hagamijwe gukura no kwirinda indwara. Kurugero, mubiryo byingurube, bikoreshwa mugipimo cyihariye ukurikije imyaka yingurube. Mu buryo nk'ubwo, mu biryo by'inkoko, byongeweho mu kuzamura imikurire n’ubuzima, nubwo bibujijwe mugihe cyo gutera. Izi porogaramu zigaragaza imikorere yingirakamaro hamwe nubwinshi mu bworozi.

Umusaruro winganda nubucuruzi bwa Oxytetracycline HCl byagutse cyane. Ibigo byinshi, nka Shanghai Zeye Biotechnology Co., Ltd., bitanga iki gicuruzwa muburyo butandukanye. Izi sosiyete zisanzwe zemeza ko zifite isuku nyinshi, akenshi zirenga 95% (HPLC), kandi zitanga ibisobanuro birambuye byibicuruzwa, harimo nimero ya CAS, uburemere bwa molekile, hamwe nuburyo bwo kubika. Hamwe nibikorwa byashinze imizi mubushakashatsi niterambere, ayo masosiyete ahora yihatira kuzamura ubuziranenge bwibicuruzwa no kwagura imirongo yibicuruzwa kugirango isoko ryiyongere.

Kwiyongera kwubucuruzi bwa Oxytetracycline HCl nabwo bwongereye ubushakashatsi mubishobora gukoreshwa birenze imikoreshereze gakondo. Mu bushakashatsi bwibinyabuzima, urugimbu rukora nkigikoresho cyingirakamaro cyo kwiga protein synthesis hamwe nibikorwa bya ribosomal. Ubushobozi bwayo bwibasira cyane bacteri ribosomal subunits ituma iba umukandida ushimishije kugirango utere imbere murwego rwo kuvumbura imiti ya antibacterial.

Byongeye kandi, ikoreshwa rya Oxytetracycline HCl mu bushakashatsi bwa electrophoreis ryerekana uburyo bukoreshwa mubushakashatsi bwibinyabuzima bya molekile. Imikoranire yihariye na ADN hamwe na bamperi ya electrophoreis bituma iba reagent yingirakamaro yo kwiga uburyo bwo kwimuka kwa ADN hamwe na bande. Ubu bushakashatsi bugira uruhare mu guteza imbere imyumvire yacu ya molekile no koroshya iterambere ryubuhanga bushya bwo gusuzuma.

Mu gusoza, Oxytetracycline HCl igaragaza ko hakomeje kubaho ubwihindurize no guteza imbere ikoranabuhanga rya antibiotique. Igikorwa cyagutse cya antibacterial ibikorwa, hamwe nuburyo bwinshi mubikorwa bitandukanye, bishimangira akamaro kayo mubushakashatsi ndetse no mubikorwa bifatika. Mugihe ibigo bikomeje kunoza uburyo bwo kubyaza umusaruro no kwagura ibicuruzwa, ibyifuzo bya Oxytetracycline HCl birashobora kwiyongera, bikarushaho gushimangira imiterere yabyo nkibuye rikomeza imfuruka mubijyanye na antibiotike.