l: Mankhwala Osiyanasiyana Osiyanasiyana a Ntchito Zosiyanasiyana

Pankhani ya mankhwala opha maantibayotiki, Oxytetracycline HCl yatulukira ngati chinthu chofunikira kwambiri chifukwa cha mphamvu zake zambiri zolimbana ndi mabakiteriya komanso kusinthasintha kwa ntchito zosiyanasiyana. Posachedwapa, gululi lakopa chidwi chachikulu kuchokera kumagulu asayansi ndi mafakitale, ndikupangitsa kuti likhale phunziro lofufuza mozama komanso lazamalonda.

Oxytetracycline HCl, yokhala ndi mankhwala ake C22H24N2O9 · HCl ndi molekyulu yolemera 496.89, ndi ufa wachikasu wa crystalline umene umakhala wokhazikika mumlengalenga koma ukhoza kudetsedwa ndi kuwala kwa dzuwa. Mankhwalawa ali m'gulu la mankhwala a tetracycline ndipo amagwira ntchito poletsa kaphatikizidwe ka mapuloteni poletsa kumangirira kwa aminoacyl-tRNA ku 30S ribosomal subunit. Zochita zake zazikuluzikulu zimaphatikiza mabakiteriya a gram-positive ndi gram-negative, zomwe zimapangitsa kukhala chida chofunika kwambiri pa kafukufuku ndi ntchito zothandiza.

Mankhwala opha maantibayotiki amadziwika chifukwa chogwira ntchito bwino pazaumoyo wa ziweto. Kafukufuku wofalitsidwa mu Poultry Science mu 1977 adafufuza za pharmacodynamics ya oxytetracycline HCl mu nkhuku. Kafukufukuyu adapeza kuti njira zonse zoyendetsera pakamwa ndi m'mitsempha zinali zogwira mtima, zokhala ndi njira zodutsa muscular and subcutaneous zomwe zimapangitsa kuti pakhale minofu yambiri. Makamaka, zitsanzo za impso ndi chiwindi zinali ndi mlingo wapamwamba kwambiri wa mankhwalawa, pamene m'mapapo ndi m'magazi a seramu nthawi zambiri anali otsika. Kafukufukuyu akugogomezera kufunikira kwa njira zoyendetsera bwino pakuwonetsetsa kuti mankhwala aperekedwa moyenera.

Kuphatikiza pa kugwiritsa ntchito thanzi la ziweto, Oxytetracycline HCl imagwiritsidwanso ntchito kwambiri pazakudya zaulimi pofuna kulimbikitsa kukula komanso kupewa matenda. Mwachitsanzo, pa chakudya cha nkhumba, chimagwiritsidwa ntchito pa mlingo wosiyana malinga ndi msinkhu wa nkhumba. Mofananamo, mu chakudya cha nkhuku, amawonjezeredwa kuti apititse patsogolo kukula ndi thanzi, ngakhale ndi zoletsedwa panthawi yobereketsa. Izi zikuwonetsa mphamvu komanso kusinthasintha kwa pagulu pauweta wa ziweto.

Kupanga kwa mafakitale ndi kupezeka kwa malonda a Oxytetracycline HCl kwakula kwambiri. Makampani angapo, monga Shanghai Zeye Biotechnology Co., Ltd., amapereka mankhwalawa mosiyanasiyana komanso kuchuluka kwake. Makampaniwa nthawi zambiri amaonetsetsa kuti chiyero chapamwamba, nthawi zambiri chimaposa 95% (HPLC), ndipo amapereka tsatanetsatane wazinthu, kuphatikizapo manambala a CAS, kulemera kwa maselo, ndi malo osungira. Ndi ntchito zozikidwa pa kafukufuku ndi chitukuko, makampaniwa amayesetsa mosalekeza kukweza mtundu wazinthu ndikukulitsa mizere yawo kuti akwaniritse zomwe msika ukufunikira.

Kuwonjezeka kwa malonda a Oxytetracycline HCl kwalimbikitsanso kafukufuku wa momwe angagwiritsire ntchito kuposa momwe amagwiritsidwira ntchito kale. Pakufufuza kwa biochemical, mankhwalawa amakhala ngati chida chofunikira powerengera kaphatikizidwe ka mapuloteni ndi ntchito ya ribosomal. Kuthekera kwake kulunjika makamaka mabakiteriya a ribosomal subunits kumapangitsa kuti ikhale yosangalatsa kuti ipitirire patsogolo pakupeza mankhwala a antibacterial.

Kuphatikiza apo, kugwiritsa ntchito Oxytetracycline HCl mu kuyesa kwa electrophoresis kukuwonetsa kugwiritsa ntchito kwake pakufufuza kwa biology ya maselo. Kulumikizana kwake kwapadera ndi DNA ndi ma electrophoresis buffers kumapangitsa kuti ikhale yothandiza powerenga ma DNA kusamuka ndi mapangidwe a magulu. Maphunzirowa amathandizira kupititsa patsogolo kumvetsetsa kwathu njira zama cell ndikuthandizira kupanga njira zatsopano zowunikira.

Pomaliza, Oxytetracycline HCl imayimira umboni wopitilira kusinthika ndi kupita patsogolo kwaukadaulo wa maantibayotiki. Ntchito yake yolimbana ndi mabakiteriya ambiri, komanso kusinthasintha kwake m'magwiritsidwe osiyanasiyana, zimatsimikizira kufunika kwake muzofufuza ndi zochitika zothandiza. Pamene makampani akupitiriza kupititsa patsogolo njira zopangira ndi kukulitsa zopereka za mankhwala, kugwiritsa ntchito kwa Oxytetracycline HCl kuyenera kukula, kulimbitsanso udindo wake monga mwala wapangodya pa nkhani ya maantibayotiki.